辛伐他汀对原发性高血压患者血清细胞因子肿瘤坏死因子和白细胞介素-6水平的影响  

Effects of Simvastatin on serum TNF-α and IL-6 levels in patients with essential hypertension

作　　者：刘忠仁[1] 韦叶生[1] 谭志辉[1] 罗章伟[1] 潘兴寿[1] 陆克兴[1] 

机构地区：[1]广西右江民族医学院附属医院心血管内科,广西白色533000

出　　处：《中国现代医学杂志》2009年第2期258-260,共3页China Journal of Modern Medicine

基　　金：广西卫生厅资助项目;(No:2003009)

摘　　要：目的观察辛伐他汀对原发性高血压患者血清细胞因子肿瘤坏死因子(TNF-α)和白细胞介素-6(IL-6)水平的影响。方法94例原发性高血压患者随机分为辛伐他汀试验组48例,对照组46例,试验组服用辛伐他汀10mg/d4周,分别于服药前后采用放射免疫分析法测定2组患者血清细胞因子TNF-α、IL-6活性水平。结果试验前,试验组和对照组的血清TNF-α、IL-6水平之间比较差异无显著性(P>0.05)。治疗4周后,试验组血清TNF-α、IL-6水平明显比对照组的血清TNF-α浓度低(P<0.05)。结论辛伐他汀通过抑制原发性高血压患者血清细胞因子TNF-α和IL-6的产生,干预原发性高血压的病理生理过程。[Objective] To investigate the effects of Simvastatin on serum TNF-α and IL-6 levels in patients with essential hypertension. [Methods] Ninety-four patients with essential hypertension were randomly divided into Simvastatin group （n =48, 10 mg daily for 4 weeks） and control group （n=46）. The serum TNF-α and IL-6 levels were detected by radioimmunoassay before and after simvastatin treatment. [Results] Before Simvastatin treatment, there was no significant difference in both TNF-α and IL-6 serum levels （P 〉0.05）. However, the serum TNF-α and IL-6 levels in Simvastatin group were lower than those in control group （P 〈0.05） after 4 weeks. [Conclusion] Simvastatin decrease serum TNF-α and IL-6 levels in patients with essential hypertention,whieh suggests Simvastatin might be beneficial to patients with essential hypertension.

关 键 词：辛伐他汀 肿瘤坏死因子 白细胞介素-6 原发性高血压 

分 类 号：R544.1[医药卫生—心血管疾病]