一种仿生型心肌组织工程生物反应器的设计  

Design on Bionic Myocardial Tissue Engineering Bioreactor.

作　　者：郭新[1] 张西正[1] 张永红[1] 王济虎[1] 徐晓莹[1] 陈明东[1] 

机构地区：[1]军事医学科学院卫生装备研究所,天津300161

出　　处：《航天医学与医学工程》2009年第1期18-21,共4页Space Medicine & Medical Engineering

基　　金：天津市自然科学基金重点项目(06YFJZJC02000);全军医药卫生科研基金面上项目(06MA344)

摘　　要：目的研制一种仿生型心肌组织工程生物反应器。方法根据心肌细胞培养的要求,设计了温度、pH值、CO2浓度、溶解氧含量参数检测和控制电路及细胞拉伸加载装置及电场刺激装置。结果实验结果表明,该生物反应器能够准确检测各项参数,并给细胞合适的拉伸频率和幅度及电场刺激。结论研制的生物反应器能够在一定程度上模拟人体心肌工作环境。Objective To develope a kind of bionic myocardial tissue bioreactor. Methods According to the requirements of cardiac cell cultivation, several circuits for measuring and controlling parameters such as temperature, pH value, CO2 concentration,O2 saturation degree, cell stretched equipment and electrical stimulating device were designed. Results The bioreactor was able to measure all parameters, and provide electrical stimulation and stretch load to cells with proper strain and frequency. Conclusion This developed bioreactor can simulate internal working circumstance of human myocardial tissue in a certain degree.

关 键 词：心肌细胞 生物反应器 组织工程 

分 类 号：R318.6[医药卫生—生物医学工程]