人涎腺腺样囊性癌嗜神经侵袭的大体形态学研究  

General morphology study of neural invasion with human salivary adonoid cystic carcinoma

作　　者：孙沫逸[1] 谭爰兴[1] 吕成鹏[1] 贾文荣[1] 李建虎[1] 杨耀武[1] 

机构地区：[1]第四军医大学口腔医学院口腔颌面外科,陕西西安710032

出　　处：《中国美容医学》2009年第2期205-207,共3页Chinese Journal of Aesthetic Medicine

基　　金：国家自然科学基金资助项目(项目编号:30271424;30772428);陕西省自然科学基金资助(项目编号:2002C2-06)

摘　　要：目的:探讨人涎腺腺样囊性癌嗜神经侵袭在大体形态学上的发生发展过程。方法:将人涎腺腺样囊性癌肺高转移癌Acc-M细胞系接种于5只裸鼠双侧臀部肌肉内,从荷瘤长出开始,解剖出荷瘤与神经以观察它们的关系,以后每隔5天在同一部位解剖一次,连续观察1个月,同时观察和对比各裸鼠神经受肿瘤侵袭后相应肢体的功能变化。结果:腺样囊性癌发生嗜神经侵袭的方式是,瘤组织细胞以神经干为中心以边生长边包裹边侵袭的方式进行的。结论:腺样囊性癌嗜神经侵袭是以一种特殊的方式进行的,这对临床诊断与治疗具有良好的指导意义。Objective To investigate development and grouth process of neural invasion with human salivary adonoid cystic carcinoma by general morphology study. Methods Human salivary adenoid cystic carcinoma line Acc-M cells were injected into intramusculary of both sides rump of five nude mice. since tumor can be seen at first, dissection of nude mice to observe their relation between tumor and nerve one time per five days, successive observation have been done for one month, at the same time, function change of all limbs with invaded nerve were observed and compared. Results Neurotropism of ACC working at the way of wraping nerve while which be grewing, and neural invasion is specific biological behaviour of adonoid cystic carcinoma. Conclusion neural invasion with adonoid cystic carcinoma were doing at a specific style, it have a good instruction sense in the clinical diagnosis and therapy.

关 键 词：腺样囊性癌 坐骨神经 神经侵袭 裸鼠 

分 类 号：Q813.1[生物学—生物工程]