CTR基因多态性及中医证型与绝经后妇女骨质疏松骨密度的关系  

Calcitonin receptor gene polymorphism and traditional Chinese medicine differentiation type in relation to bone mineral density in female patients with postmenopausal osteoporosis

作　　者：赵云芳 陈荣庄[2] 白董[2] 王炳南[3] 

机构地区：[1]东莞市常平医院外一科,东莞523563 [2]广州中医药大学 [3]广州中医药大学附属骨伤科医院

出　　处：《中国骨质疏松杂志》2009年第2期99-102,共4页Chinese Journal of Osteoporosis

摘　　要：目的观察降钙素受体（CTR）基因多态性及中医证型与绝经后妇女骨质疏松骨密度的关系。方法选择2006年7月至2008年2月绝经后骨质疏松症患者120例，采用双能x线骨密度仪测定部位骨密度，中医辩证分型，记录患者年龄、绝经年龄、绝经年限、身高、体质量等自身因素，应用聚合酶链反应检测降钙素受体基因多态性。结果CTR基因型分布：CC型74．17％，CT型21．67％，TT型4．17％；中医证型分布：脾肾阳虚型71．67％，肝肾阴虚型22．50％，气滞血瘀型7例5．83％。经t检验，不同CTR基因型者间骨密度差异无统计学意义；各中医证型者骨密度间差异无统计学意义。在CC型中，气滞血瘀的腰椎骨密度明显低于脾肾阳虚（P〈0．05）。结论降钙素受体基因多态性及中医证型与绝经后骨质疏松症骨密度存在相关性。Objective To study the relationship between the Calcitonin receptor （CTR） gene polymorphism uniting traditional Chinese medicine （TCM） differentiation type and bone mineral density （BMD） in female postmenopausal osteoporosis （POP）. Methods 120 patients with postmenopausal osteoporosis were investigated from July 2006 to February 2008. They all knew the fact and accepted. The BMD of the 2th-4th lumbar vertebrae, left upper femur, greater troehanter and Ward＇s area was measured with dual energy X-ray absorptiometry. Selffactor of patients were recorded. The CTR gene polymorphism was detected by polymerase chain reaction. Normal data were compared with t-test, no normal data were compared with Wilcoxon rank sum test, and relationship between self-factors and BMD were analyzed with Bivariate method. Results Totally 120 POP patients entered the final analysis. BMD of POP patients with 3 kinds CTR was not significantly different from that of patients with various TCM differentiation types, and differences among 3 kinds of TCM differentiation types were not significant; In CC genotype, BMD of the 2th-4th lumbar vertebrae in qi-stagnancy and blood stasis patients was significantly lower than that in asdthenic splenonephro-yang patients. Conclusion The polymorphism of CTR gene uniting TCM differentiation type is correlated with BMD in POP.

关 键 词：中医证型 绝经后骨质疏松 骨密度 降钙素受体基因多态性 

分 类 号：R589.5[医药卫生—内分泌]