手性拆分剂D／L-二苯甲酰酒石酸的制备  

Synthesis of D/L-Dibenzoyl Tartaric Acid

作　　者：郭卫锋 应瑞芬[2] 陈新良 舒理建 黄成军[2] 

机构地区：[1]浙江普洛康裕制药有限公司,浙江东阳322118 [2]上海医药工业研究院,上海200437

出　　处：《中国医药工业杂志》2009年第2期92-93,共2页Chinese Journal of Pharmaceuticals

摘　　要：用D/L-酒石酸和过量的苯甲酰氯反应得D/L-二苯甲酰酒石酸酐,利用原料、产物和副产物在甲苯中的溶解度差异,可得到苯甲酸残留量低于0.1%的D/L-二苯甲酰酒石酸。The resolving agent D- or L-dibenzoyl tartaric acid, was prepared by the acylation of D- or L-tartaric acid with excess of benzoyl chloride to give dibenzoyl tartaric anhydride, followed by hydrolysis with an overall yield of 82 %. The residual benzoic acid in the product was controlled to below 0.1% by work-up with toluene.

关 键 词：苯甲酸 D/L-二苯甲酰酒石酸 手性拆分剂 制备 

分 类 号：O625.52[理学—有机化学]