大剂量静注免疫球蛋白治疗伴免疫异常的神经系统疾病  

Intravenous Administration of Immunoglobulin for the Treatment of Nervous Systemic Diseases with Abnormal Immune State

作　　者：黄煜敏[1] 潘家杰[1] 杨建设[1] 罗达人 陈勇[1] 张梁[1] 郭元元 李晓军[1] 王宏[1] 

机构地区：[1]石河子医学院第一附属医院,石河子832008

出　　处：《中国神经免疫学和神经病学杂志》1998年第1期39-43,共5页Chinese Journal of Neuroimmunology and Neurology

摘　　要：目的观察大剂量免疫球蛋白治疗伴免疫异常的神经系统疾病的效果。方法予患者静注大剂量人血免疫球蛋白，记录治疗后不同时间内的病情变化、体征和有关辅助检查。结果静注免疫球蛋白对重症肌无力、多发性硬化、多数单神经病、多发性肌炎、Takayasu病及难治性癫痫疗效好，特别是对重症肌无力伴呼吸和吞咽麻痹有快速改善症状的作用，还可对抗由肾上腺皮质激素减量引起的反跳作用；对运动神经元病和小脑变性无效。结论静注免疫球蛋白对神经系统自身免疫性疾病和与免疫反应有关的疾病疗效好，对变性或遗传病疗效不佳或无效。Objective It was designed to evaluate the effect of high dose intravenous injection ofimmunoglobulin (IVIg) on nervous systemic diseases with abnormal immune state. Method14 cases were treated with high dose IVIg. The authors observed clinical pictures, signsand relevant laboratory tests at different time after the therapy. Results It was found thatIVIg was a successful therapy for myasthenia gravis (MG), especially with respiratory andswallowing difficulties, multiple sclerosis (MS), mononeuritis multiplex (MNM ),polymyositis and Takayasu's disease, but had little or no effect on degenerative or hereditarydiseases. IVIg could alleviate the rebound phenomenon during tapering adrenal corticosteroids. Conclusion IVIg was effective on various autoimmune diseases of nervous system.

关 键 词：免疫球蛋白 神经系统 治疗 免疫异常 

分 类 号：R977.8[医药卫生—药品] R741.05[医药卫生—药学]