奥美拉唑肠溶片在汉族健康人体的药动学研究  

Pharmacokinetics of Omeprazole Enteric-coated Tablets in Healthy Volunteers

作　　者：孙昨明[1,2] 夏东亚[2] 郭涛[2] 隋因[2] 唐云彪[2] 颜鸣[2] 

机构地区：[1]沈阳药科大学,沈阳市110016 [2]沈阳军区总医院药剂科,沈阳市110016

出　　处：《中国药房》2009年第5期344-346,共3页China Pharmacy

基　　金：全军医学科学技术研究"十一五"计划科技攻关课题基金资助项目(06G023)

摘　　要：目的：研究奥美拉唑在汉族健康人体的药动学。方法：选择10名健康受试者，男女各半，单剂量口服奥美拉唑肠溶片40mg后，于不同时间点采静脉血，经血浆样品处理后用高效液相色谱法测定人血浆中奥美拉唑的浓度。用DAS2．0药动学软件进行数据处理，SPSS 11．5软件进行统计分析。结果：主要药动学参数Cmax为（760．49±581．232）μg·L^-1,tmax为（2．7±0．823）h，t1/2为（1．601±1．282）h，AUC0-12为（1437．61±798．045）μg·h·L^-1，AUC0-∞。为（1470．09±769．475）μg·h·L^-1.主要药动学参数与文献报道基本一致，且性别间主要药动学参数差异无统计学意义。结论：本方法可用于奥美拉唑的药动学研究。OBJECTIVE： To study the pharmacokinetics of omeprazole in healthy volunteers. METHODS： 10 healthy volunteers （5 females and 5 males） were given a single oral dose（40 mg） of omeprazole tablets. Venous blood samples were collected at different time and subjected to sample treatment before the HPLC determination of the concentration of omeprazole in plasma samples. The parameters were treated using DAS 2.0 pharmacokinetics software and analyzed using SPSS 11.5 software. RESULTS： Themain pharmacokinetic parameters of omeprazole were as follows： Cmax（760.49± 581.232）μg·L^-1; t （2.7± 0.823）h;t1/2（1.601±1.282）h; AUC0-12（1437.61±798.045）μg·L^-1AUCo-∞,（1470.09±769.475）μg·L^-1, which were in line with those reported in literature and of no statistical significance between different sex. CONCLUSION： The method adopted in our study can be used for the pharmacokinetic study of omeprazole.

关 键 词：奥美拉唑 高效液相色谱法 药动学 

分 类 号：R969.1[医药卫生—药理学]