注射用加替沙星与头孢硫脒的配伍稳定性考察  

Compatible Stability of Gatifloxacin for Injection in Combination with Cefathiamidine for Injection

作　　者：刘瑞琴[1] 杨继章[1] 

机构地区：[1]河北医科大学第一医院,石家庄市050031

出　　处：《中国药房》2009年第5期359-361,共3页China Pharmacy

基　　金：河北省医学科学研究重点课题(04177)

摘　　要：目的:考察注射用加替沙星与头孢硫脒在0.9%氯化钠注射液和5%葡萄糖注射液中配伍的稳定性。方法:分别观察及测定配伍液在室温(20±1)℃下放置8h内的外观、pH值变化,并用紫外双波长分光光度法测定其含量。结果:2药在0.9%氯化钠注射液、5%葡萄糖注射液中配伍后8h内外观、pH值、含量、紫外吸收峰形无显著变化。结论:注射用加替沙星与头孢硫脒可以在0.9%氯化钠注射液、5%葡萄糖注射液中配伍使用。OBJECTIVE： To study the compatible stability of gatifloxacin for injection in combination with cefathiamidine for injection in 0.9% sodium chloride injection or in 5% glucose injection. METHODS： Changes in appearance and pH value of the mixture of gatifloxcation and cefathiamidine within 8 hours after mixing were respectively observed and determined under room temperature （20± 1）℃, and the contents were determined by dual ultraviolet spectrophotometry. RESULTS： The appearance, pH value and contents as well as the ultraviolet absorption peak shape of the mixture showed no significant change within 8 hours after mixing in 0.9% sodium chloride injection or 5% glucose injection. CONCLUSION： Gatifloxacin for injection can be mixed with cefathiamidine for injection in 0.9% sodium chloride injection or 5% glucose injection to use.

关 键 词：加替沙星 头孢硫脒 配伍 稳定性 紫外分光光度法 

分 类 号：R927.11[医药卫生—药学]