可逆性后部脑病综合征诊治进展  

Review of posterior reversible encephalopathy symdrome

作　　者：郝红琳[1] 崔丽英[1] 高晶[1] 刘秀琴[1] 黄颜[1] 张之诤 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院神经内科,北京100730

出　　处：《中国实用内科杂志》2009年第2期169-171,共3页Chinese Journal of Practical Internal Medicine

摘　　要：可逆性后部脑病综合征是以头痛、抽搐、意识障碍、视力改变为主要临床特点的综合征,其确切病因及机制尚不清楚,血压急性增高、妊娠及产后子痫、各种原因肾病及肾衰竭、结缔组织病、免疫抑制和细胞毒性药物等与本病发病有关,其发病机制有脑灌注压突破、血管内皮细胞受损等。典型的影像学可见双侧对称性分布、多灶性、主要累及后部脑区的病灶。治疗主要包括控制原发病、减轻脑水肿、降压、抗癫痫等,一般预后良好,病程可逆。Posterior reversible encephalopathy symdrome is the syndrome characterized by headache, seizures, confusion, visual disturbances. The exact etiology and mechanism remain unclear. The spectrum of associated diseases is diverse, including acute rise in blood pressure, eclampsia, various renal disease and renal failure, connective tissue disease, immunosuppressive or cytotoxic medication are associated with PRES. The mechanisms included breakdown of cerebral perfusion pressure, damage of vascular endothelial cell, and so on. Typical radiological findings are bilateral symmetric, multifocal lesion distributed in posterior regions of the cerebral hemisphere. Treatment includes decreasing cerebral edema, antiepileptic drugs, decreasing blood pressure. Generally, it is reversible and benign.

关 键 词：可逆性后部脑病综合征 脑灌注压突破 血管内皮细胞受损 

分 类 号：R5[医药卫生—内科学]