脂蛋白相关磷脂酶A2浓度与兔动脉粥样硬化关系的研究  

Relationship between lipoprotein-associated phospholipase A2 concentration and arteriosclerosis in rabbits

作　　者：唐建花[1] 王卫淑[1] 裴志强[2] 王会龙[3] 

机构地区：[1]山西医科大学第二医院干部保健科,太原030001 [2]太原市中心医院科教科 [3]山西医科大学第二医院风湿免疫科,太原030001

出　　处：《中国药物与临床》2009年第2期108-110,共3页Chinese Remedies & Clinics

基　　金：山西省自然科学基金(20080111074-2)

摘　　要：目的研究血清脂蛋白相关磷脂酶A2浓度与高胆固醇血症兔动脉粥样硬化的关系。方法将48只健康雄性新西兰白兔随机分成2组:对照组,高脂饮食组。制备高胆固醇血症的动物模型,分别于0,4,8,12周留取雄兔血清。测定血脂和脂蛋白相关磷脂酶A2浓度,并在光镜下观察兔主动脉的病理形态改变。结果①饲喂4,8,12周后,与对照组相比,高脂饮食组血清总胆固醇、低密度脂蛋白胆固醇升高(P<0.01);高密度脂蛋白胆固醇较对照组升高(P<0.05),但总体有下降趋势;②饲喂8周后,高脂饮食组血清甘油三酯开始明显升高(P<0.01);③饲喂4,8,12周后,与对照组相比,高脂饮食组血清脂蛋白相关磷脂酶A2浓度较对照组升高(P<0.01)。结论脂蛋白相关磷脂酶A2有促进动脉粥样硬化的作用。Objective To study the relationship between lipoprotein-associated phospholipase A2 concentration and arteriosclerosis in the hyperlipemic rabbits. Methods Forty-eight healthy male New Zealand rabbits were randomly divided into control group and high-fat diet group. Hyperlipemia models were established in male rabbits, which were collected of fasting serum samples for tests of blood lipids and lipoprotein-associated phospholipase A2 concentrations at weeks 0, 4, 8 and 12. Meanwhile, the arteries of rabbits were studied under optical microscope for morphological changes. Results ①Among rabbits on high-fat diet, levels of total cholesterol （TC） and low density lipoprotein cholesterol （LDL-C） were higher than those among controls at weeks 4,8 and 12 （P〈0.01）, so was the level of high density lipoprotein cholesterol （HLD-C） but this appeared declining over the weeks （P〈0.05）. ②After 8 weeks, level of triglycerides began to increase in the high-fat diet group （P〈0.01）. ③Rabbits on high-fat diet showed higher levels of lipoprotein-associated phospholipase-A2 （LP-PLA2） as compared with controls at weeks 4,8 and 12 （P〈0.01）. Conclusion Lipoprotein-associated phospholipase-A2 （LP-PLA2） seems to have a role in the progression of arteriosclerosis.

关 键 词：脂蛋白相关磷脂酶A2 动脉粥样硬化 高胆固醇 低密度脂蛋白 

分 类 号：R543[医药卫生—心血管疾病]