慢性铅暴露对大鼠海马CA_1区长时程增强的影响  

Effects of Chronic Exposure to Lead on in Vivo Induction of LongTerm Potentiation in Rat Hippocampal CA1 Area

作　　者：刘君澜[1,2] 高奎斌[1,2] 时利德[1,2] 万伯健[1,2] 蔡原[1,2] 

机构地区：[1]中国医科大学卫生毒理学教研室 [2]中国医科大学脑研究所神经生理室

出　　处：《劳动医学》1998年第1期7-10,共4页

基　　金：国家自然科学基金

摘　　要：本研究采用神经生理细胞外玻璃微电极记录方法，观察了慢性铅暴露对年幼大鼠海马ＣＡ１区ＬＴＰ的影响。结果表明：铅暴露组与对照组比，ＰＴＰ的平均群体峰电位振幅增强率无明显差别；ＬＴＰ发生率及平均ＰＳ电位幅值增强率显著降低。ＰＳ电位增强率与脑铅浓度呈显著负相关。提示慢性铅暴露可损害年幼大鼠海马ＣＡ１区的ＬＴＰ的诱导和维持。This study with the method of extracellular glass microelectrode recording of neurophysiology,examined the effects of chronic exposure to lead on young rats' LTP of hippocampal CA1 areas.In contrast,no significant changes were found in population spike amplitudes of posttetanic potentiation of Pbexposed rats;the incidence of LTP and average population spike amplitudes increase rate were markedly decreased.Population spike potentiation increase rate is markedly correlated with brain lead concentration in negative direction.It suggested chronic exposure to lead impaired the LTP's induction and maintenance of hippocampus CA1 area of young rats.

关 键 词：铅暴露 海马 长时程增强 无机毒物 毒理学 铅 

分 类 号：R995[医药卫生—毒理学]