载氧适应预防急性高原病的作用及机制  

Effect and Mechanism of Carrying Oxygen Adaptation Preventing the Acute Mountain Sickness

作　　者：周其全[1] 张雪峰 杨景义[3] 

机构地区：[1]兰州市解放军兰州医高专 [2]青海省格尔木市医院 [3]兰州市解放军第四医院

出　　处：《解放军医学高等专科学校学报》1998年第1期1-3,共3页Clinical Journal of Medical Officer

摘　　要：作者对不同急进高原人群进行观察，结果表明其急性高原病的发病率明显降低，仅为２．６％；而未载氧人群（对照组）急性高原病的发病率高达１６．１％。载氧后血液动力学检查结果表明，载氧能降低血压、减慢心率、明显增加心脏每博量和每分心输出量。同时结果表明，载氧能明显增加血浆皮质醇的含量和血清ＳＯＤ活性，延缓Ｈｂ的增长速度。动物实验表明载氧不能增加小鼠对缺氧的耐受性，但却能增加皮质醇、皮质酮的含量。因此作者认为载氧适应能预防急性高原病，并不是其皮下“氧气库”的作用，可能是通过某些适应机制来提高机体的应激能力，从而使机体尽快适应高原环境。In order to prevent the development of acute mountain sickness, the authers injected oxygen into subcutaneous tissues of waist to prevent the acute mountain sickness and achieved obvious effect.As to further research the effect and mechanism of carrying O2 adaptation, we have further observed different kinds of rapid entering people to plateau.The results showed that in carrying O2 people entering peopeo high altitude region the morbidity of acute mountain sickness reduced obviously, and was only 26% per cent, but in noncarrying O2 people (control group) was 161% per cent.The animals experiments showed that carrying O2 can′t increased the tolerance of rats on hypoxia, but can increase the plasma cortisol and corticosterone content.Therefore we thought that carrying O2 can prevent the acute mountain sicknesss, but its effect did not come from the subcutaneous “oxygen garage”, but through certain adaptative mechanisms to raise the stress ability of body.

关 键 词：高海拔区 急进人群 高原病 载氧适应 

分 类 号：R594.3[医药卫生—内科学]