基质金属蛋白酶和心肌梗死后心室重构  

Matrix metalloproteinases and ventricular remodeling after myocardial infarction

作　　者：洪志斌[1] 问肃生 张远征[1] 

机构地区：[1]甘肃省天水市第一人民医院心内科,甘肃天水741000

出　　处：《国际内科学杂志》2009年第1期30-33,共4页International Journal of Internal Medicine

摘　　要：心肌梗死后心室重构是慢性心力衰竭发展的重要病理基础,延缓或阻止心室重构已成为慢性心力衰竭的主要治疗方法。基质金属蛋白酶是一组与心室胞外基质重构有关的水解酶,抑制基质金属蛋白酶的表达和活性对心室重构的防治有重要意义。Ventricnlar remodeling after myoeardial infarction is important fnndament of heart failure development. Preventing ventrieular remodeling has been a main method for treating chronic heart failure. Matrix metalloproteinases is hydrolyase that is concerned with extracellular matrix remodeling. It has important role for preventing ventricular remodeling by inhibiting expression and activity of matrix metalloproteinases.

关 键 词：基质金属蛋白酶 心肌梗死 心室重构 

分 类 号：R542.22[医药卫生—心血管疾病]