胃动素对迷走传入神经放电的影响  

The effect of motilin on vagal afferent nerve

作　　者：李静[1] 邓丽君[1] 肖刚[1] 陆杰[2] 

机构地区：[1]重庆医科大学基础医学院生理教研室,重庆400016 [2]重庆医科大学基础医学院机能教研室,重庆400016

出　　处：《南京医科大学学报（自然科学版）》2009年第2期166-171,共6页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的:探讨胃动素对膈下迷走神经传入自发放电和扩胃诱发放电的影响及其相应的机制。方法:实验在SD大鼠身上进行,记录膈下迷走神经传入自发和扩胃诱发的放电变化,静脉注射不同剂量胃动素,以及先用昂丹司琼、阿托品处理再给胃动素观察其变化。结果:小剂量胃动素(1μg/kg)自发和诱发均无无显著变化;中剂量(5μg/kg)和大剂量(40μg/kg)胃动素注射后,自发放电和诱发放电均显著增加;昂丹司琼能够完全阻断大剂量的作用;阿托品对大剂量胃动素作用有改变,但无统计学意义。昂丹司琼能够单独阻断迷走传入神经放电,阿托品对迷走传入放电有抑制作用,前者有统计意义而后者无。结论:胃动素引起迷走传入自发和诱发放电增加,迷走传入神经参与了胃动素对胃肠感觉影响后的传递,而5-HT3受体也可能与这种传递有关。Objectives：To investigate the effect of motilin on spontaneous afferent nerve discharge and gastric distention-induced afferent nerve discharge and explore the corresponding mechanism. Methods：Experiments were performed in anesthetized SD rats. The sensory impulses of subdiaphragmatic vagal nerve were recorded by the RECORDER. Different dosages of motilin were intra-venous injection. Some rats were pretreated with andansetron and atropine, and then injected high-dose motlin. Results：Intravenous low mofilin（1 μg/kg） had no effect, and intravenousmedium and high motilin（5μg/kg and 40 μg/kg respectively） caused obvious increase of spontaneous afferent discharge and gastric distention-induced afferent discharge. Pretreatment with ondansetron almost completely blocked the effects of motilin. Atropine had no obvious influence with the effect of high-dose motilin. Ondansetron inhibited afferent nerve discharge by itself, and atropine also did, but it failed to reach statistical significance. Conclusian：Motilin can excite spontaneous afferent nerve discharge and gastric distention-induced afferent nerve discharge. Vagal afferent nerve may play an important role in motilin transferring gastrointestinal information, 5-HT3 receptor are probably involved in the effect, but not atropine.

关 键 词：胃动素 迷走传入神经 昂丹司琼 阿托品 

分 类 号：R338[医药卫生—人体生理学]