微分脉冲伏安法测定肠溶片剂中吲哚美辛的含量  

Differential Pulse Stripping Voltammetric Determination of Indometacin in Pharmaceuticals

作　　者：倪永年[1,2] 李淑贞[1] 

机构地区：[1]南昌大学食品科学与技术国家重点实验室,江西南昌330047 [2]南昌大学化学系,江西南昌330031

出　　处：《南昌大学学报（理科版）》2008年第6期568-570,共3页Journal of Nanchang University(Natural Science)

基　　金：国家自然科学基金资助项目(20562009);江西省自然科学基金资助项目(0620041);中科院长春应化所电分析化学重点实验室资助项目(SKLEAC2004-3);长江学者及创新团队资助项目(IRT0540)

摘　　要：应用微分脉冲伏安法研究了药物吲哚美辛水解产物的电化学行为及其测定方法。吲哚美辛本身在金电极上不具有电化学活性，但在稀NaOH溶液中，并在沸水浴条件下它能发生水解反应，水解产物则具有很强的电化学响应。电位扫描后可得一灵敏的氧化峰，峰电流与吲哚美辛浓度成正比，线性范围为0．2—2．2μg／mL，检出限为0．073μg/mL。该方法用于药品中的吲哚美辛的测定，结果满意。A differential pulse voltammetry method for the determination of indometacin was proposed. The electro- chemical behavior and vohammetric parameters of indometacin at the gold electrode were studied and evaluated. Indometaein was hydrolyzed in the solution of NaOH with water - bath at 100 ℃, then a sensitive oxidative peak could be observed for its hydrolyzed product, and the peak current was linear with its concentration in the range of 0. 2 - 2.2 μg/mL with the detection limit of 0. 073 μg/mL. It was demonstrated that the proposed method was simple, easy to operation and hard to be interfered. The proposed method was applied to the determination of indometacin in pharmaceutical preparations with satisfactory results.

关 键 词：吲哚美辛 微分脉冲溶出伏安法 测定 

分 类 号：O657.14[理学—分析化学]