阿苯达唑及其中间代谢物在人尿中含量的测定  

DETERMINATION OF ALBENDAZOLE AND ITS INTERMEDIATES IN HUMAN URINE

作　　者：关天颖[1] 刘淑珍[1] 贾忠山[1] 孙晓秋[1] 郑连舫 李惠淑 金顺姬 

机构地区：[1]吉林农业大学

出　　处：《吉林农业大学学报》1990年第2期92-97,共6页Journal of Jilin Agricultural University

摘　　要：阿苯达唑(Albendazole)为新型广谱驱虫药,应用于治疗囊虫病取得了较好疗效。据报道,阿苯达唑进入人体经肝微粒体单氧加氧酶p-450、NADPH FP_1及FP_2的作用下,转化成阿苯达唑亚砜,为治疗囊虫病的有效成分;继而转化成砜、二氨基砜而失活,据作者实测结果,尿中含有大量阿苯达唑亚砜和砜,尚未转化成最终产物便从尿中排出。而致使血中亚砜浓度迅速下降。通过实测数据,为临床治疗提供参考。A RP-HPLC mthod was used for assay of sulfoxide and sulfone in human urine after a single oral dose of 25mg albendazole per kilo body weignt. 0.04% metnanol containing acetic acid is employed as mobile phase, and Micro Bondpak [CN 0.39×l5cm l0μ as stationary phase column. U-V detector at 290nm; Mebendazole as internal standard were used. The rates of recovery of the sulfoxide and sulfone in the urine were 98.95 ± 8.9% and 95.81±15.23% respectively. The time of sulfoxide and sulfone peak in the urine of patients occurred 14 hours after taking the albendazole. The means of sulfoxide and sulfone peak values n the urine were 36344.09± 2563.72ng/ml and 3617. 38±570.80/ml, respectively.

关 键 词：阿苯达唑 代谢物 人尿 测定 

分 类 号：R446.122[医药卫生—诊断学]