鱼类及其他脊椎动物神经递质含量的比较研究  

Comparative Study on Neurotransmitter Content of Fishes and Other Vertebrates

作　　者：王鸿泰[1] 王莉莎 吴恢碧[1] 郑蓓蓓[1] 李耀彩 

机构地区：[1]中国水产科学研究院长江水产研究所,湖北荆州434000 [2]北京市305医院,北京100017 [3]湖南省益阳市畜牧水产局,湖南益阳413000

出　　处：《长江大学学报（自科版）（中旬）》2008年第4期52-56,共5页Journal of Yangtze University(Nature Science Edition)

摘　　要：采用高效液相色谱法测定了变温动物(鱼、蛙、鳖)和恒温动物(鸡、狗、牛)脑和脊髓中多巴胺(DA)和5-羟色胺(5-HT)的含量。结果表明:(1)变温动物和恒温动物脑和脊髓中DA和5-HT含量存在较大差异。变温动物脑和脊髓中DA含量分别为(0.228±0.014)μg/g和(0.155±0.003)μg/g,5-HT含量分别为(0.465±0.139)μg/g和(0.104±0.004)μg/g;恒温动物脑和脊髓中DA含量分别为(0.258±0.015)μg/g和(0.236±0.018)μg/g;脑和脊髓中5-HT为(1.020±0.166)μg/g和(0.712±0.344)μg/g。(2)湖泊与池塘的鲢脑中DA含量分别为(0.197±0.018)μg/g和(0.073±0.012)μg/g,血液中肾上腺素(Ad)含量分别为(0.065±0.013)μg/g和(0.025±0.007)μg/g。这说明DA和Ad在鱼类环境应激中有重要作用。(3)从鱼类经鸟类到哺乳类纵向比较,其神经递质的含量是不同的。以进化论和全息论的观点来看,其中可能蕴藏着生物医药潜力。The dopamine (DA) and 5-hydroxyindoleaceti (5-HT) in coldblooded (fish,frogs,turtles) and warmblooded (hens,dogs,cows) was measured in high performance liquid chromatography. The results showed as follows:(1) DA of coldblooded in brain and spinal were (0.228±0.014) μg/g,(0.155±0.003) μg/g,respectively. 5-HT of coldblooded in brain and spinal were (0.465±0.139) μg/g,(0.104±0.004) μg/g,respectively. DA of warmblooded in brain and spinal were (0.258±0.015) μg/g,(0.236±0.018) μg/g,respectively. 5-HT of warmblooded in brain and spinal were (1.020±0.166) μg/g,(0.712±0.344) μg/g,respectively. (2) DA and adrenalin (Ad) of siver carp in the lake and pond showed that the contents of them were different which proved that DA and Ad played a great role in environment stress-response of fishes. (3) The vertical comparison of the neurotransmitter from the fishes,through the bird,and to the mammal showed that its content was different. According to the biological evolution and hologram theory,perhaps in their central nervous system could contain potential biological medicine.

关 键 词：多巴胺 5-羟色胺 鱼类 脊椎动物 生物进化论 环境应激 

分 类 号：Q42[生物学—神经生物学]