110例假丝酵母菌属感染与药敏结果分析  

Susceptibility to Antifungal Agents in 111 Candida Strains Causing Nosocomial Deep Fungal Infections

作　　者：杨玉林[1] 郭凤玲[1] 史跃杰[1] 郭艳梅[1] 

机构地区：[1]河南省中医院检验科,河南郑州450002

出　　处：《中华医院感染学杂志》2009年第3期355-357,共3页Chinese Journal of Nosocomiology

摘　　要：目的研究假丝酵母菌属的临床分布及其对抗真菌药物的敏感性。方法假丝酵母菌属分离培养采用科玛嘉显色培养基,药敏试验采用K-B法,观察111株假丝酵母菌属对益康唑(ECO)、制霉菌素(NYS)、伊曲康唑(ITR)、酮康唑(KET)、氟康唑(FLU)、5-氟胞嘧啶(FCT)、两性霉素B(AMB)的敏感性。结果111株假丝酵母菌属中,以白色假丝酵母菌最常见,占70.27%,其次为热带假丝酵母菌占21.62%,其他假丝酵母菌占8.1%;假丝酵母菌属感染的原发疾病依次为肿瘤、呼吸系统、循环系统、消化系统、血液系统、内分泌、泌尿系统疾病;假丝酵母菌属对抗真菌药物的敏感性依次为制霉菌素、两性霉素B、伊曲康唑、5-氟胞嘧啶、酮康唑、氟康唑、益康唑。结论真菌感染与原发病及老龄化等因素密切相关;合理使用抗菌药物、提高机体免疫力是预防住院患者真菌感染的主要措施。OBJECTIVE To study pathogen distribution and susceptibility to sevenral antifungal agents. METHODS The CHROMagar candida color medium was applied to isolate and identify Candida strains. Drug sensitivity was analyzed by the K-B diffusion method. The drug sensitivity to econazole（ECO）, nystatin（NYS）, itraconazole （ITR）, ketoconazole （KET）, fluconazole （FLU）, flucytosine （FCT）, and amphotericin B （AMB） was tested. RESULTS Candida albicans was the most frequent isolated organism accounting for 62. 5%. C. tropicalis and others accounted for 21.62% and 8.1%, respectively. The respiratory tract infection accounted for 76.57%, and the urinary tract was the second （6.31%）, the blood and genitourinary tract were the third（5. 00%）. The susceptibility of Candada spp strains to nystatin and amphotericin B was more active than to other antifungal agents. CONCLUSIONS The fungal infection is relative to some risk factors, such as using antibiotics, underlying diseases and aging. Therefore, using antibiotics reasonably and improving the immunity are the main measures of preventing the fungal infection.

关 键 词：真菌感染 药物敏感试验 假丝酵母菌属 

分 类 号：R379.4[医药卫生—病原生物学]