常用抗病毒药物对SARS疗效的多因素分析  

Antiviral Agents in Treating Severe Acute Respiratory Syndrome:A Multi-factorial Analysis

作　　者：刘冬生[1] 欧阳菊香[1] 邹敏超[2] 梁一霞[1] 廖红英[1] 廖珊[1] 

机构地区：[1]佛山市第一人民医院信息科,广东佛山528000 [2]佛山市第二人民医院传染科,广东佛山528000

出　　处：《中华医院感染学杂志》2009年第4期434-436,共3页Chinese Journal of Nosocomiology

基　　金：佛山市医学科研立项课题(2007030)

摘　　要：目的评估6种常用抗病毒药物对SARS的治疗效果。方法利用广东省卫生厅提供的1702例SARS患者的病史、体征和治疗的详细资料,采用单因素和多因素的方法对SARS患者的死亡和病程的影响因素进行回顾性分析。结果6种抗病毒药物均无有效降低SARS患者的死亡率,但阿糖腺苷有助于缩短病程(OR值=1.399,P=0.025),而奥司他韦可能使病程延长(OR值=0.708,P=0.000)。结论目前常用的这6种抗病毒药物对SARS的治疗效果有限,有待今后进一步探索新的抗病毒治疗方法。OBJECTIVE To evaluate the effect of antiviral agents in treating of severe acute respiratory syndrome （SARS）. METHODS Based on the particular data （including medical history, examiuations and treatments） of 1702 patients of with SARS which were offered by the Health Bureau of Guangdong Province, the inpact factors of death and the course of diseases of SARS were retrospectively analyzed with unifactorial and multifactors statistic analysis methods. RESULTS It did not show any signs that the death rate could be decreased by the six antiviral agents in common use, but vidarabine could help to shorten the course of disease（OR=1. 399,P=0. 025）, while oseltamivir might be prolonged the course of disease（OR=0. 708, P=0. 000）. CONCLUSIONS The data showed that the effect of the six antiviral agents for curing SARS is limited, and a new antiviral treatment for SARS should be explored further.

关 键 词：严重急性呼吸综合征 抗病毒药 药物评价 

分 类 号：R978.7[医药卫生—药品]