临床分离48株嗜麦芽寡养单胞菌耐药性检测  

Resistance of 48 Clinical Isolates of Stenotrophomonas maltophilia

作　　者：周典[1] 魏艳艳[1] 熊自忠[1] 王中新[1] 

机构地区：[1]安徽医科大学第一附属医院,安徽合肥230022

出　　处：《中华医院感染学杂志》2009年第4期456-457,共2页Chinese Journal of Nosocomiology

基　　金：安徽省自然科学基金(050430804)

摘　　要：目的了解临床分离嗜麦芽寡养单胞菌对常用抗菌药物的耐药性,为临床合理用药提供依据。方法琼脂稀释法或纸片扩散法测定48株嗜麦芽寡养单胞菌对7种抗菌药物的敏感性。结果嗜麦芽寡养单胞菌对替卡西林/克拉维酸的耐药率最低(12.5%),其次为米诺环素(25.0%)和复方新诺明(31.3%);其余抗菌药物耐药率均≥50.0%,对头孢他啶、头孢他啶/舒巴坦、氯霉素、左氧氟沙星的耐药率分别为62.5%、52.1%、52.1%、50.0%。结论嗜麦芽寡养单胞菌对替卡西林/克拉维酸、米诺环素、复方新诺明较敏感,对其他抗菌药物耐药情况严重,临床上应加强检测和监测。OBJECTIVE To investigate the resistance in clinical isolates of Stenotrophomonas maltophilia to antimicrobial agents. METHODS Susceptibility of 48 S. maltophilia isolates were tested by agar dilution or K-B method. RESULTS The lowest resistance rate of isolates to the antimicrobial agents was to ticarcillin/clavulanic acid （12.5%）, then to minocycline （25.0%） and trimethoprim/sulfamethoxazole （31.3%）. The resistance rate to ceftazidime, ceftazidime/sulbactam, levofloxacin, and chloramphenicol was 62. 5%, 52. 1%, 52. 1%, and 50. 0%, respectively. CONCLUSIONS Most of S. maltophilia isolates are susceptible to ticarcillin/clavulanic acid, minocycline, trimethoprim/sulfamethoxazole and resistant to other antimicrobial agents. More mornitoring should he enhanced.

关 键 词：嗜麦芽寡养单胞菌 抗菌药物 耐药性 

分 类 号：R378[医药卫生—病原生物学]