孕妇被动吸烟与小于胎龄儿关系的Meta分析  

A Meta-analysis on the association between maternal passive smoking during pregnancy and small- for - gestational - age infants

作　　者：刘涛[1] 陈维清[1] 何艳辉[1] 丁鹏[1] 凌文华 

机构地区：[1]中山大学公共卫生学院医学统计与流行病学系,广州510080 [2]公共卫生学院

出　　处：《中华流行病学杂志》2009年第1期68-72,共5页Chinese Journal of Epidemiology

基　　金：基金项目：国家自然科学基金资助项目（30872164）;中华医学基金会（CMB）资助项目（00-729）.

摘　　要：目的探讨孕妇孕期被动吸烟与小于胎龄儿之间的关系，分析不同孕期和不同地点被动吸烟的效应。方法利用Meta分析方法综合分析国内外8篇关于孕妇孕期被动吸烟与小于胎龄儿关系的回顾性研究文献。结果孕妇孕期被动吸烟与小于胎龄儿之间的粗合并效应值OR=1.45（95％CI：1.05-2.01），调整合并效应值OR=1.76（95％CI：1.15-2.69）；孕妇孕早期被动吸烟的合并效应值OR=1.85（95％CI：1.25-2.72），孕中晚期被动吸烟的合并效应值OR=2.12（95％CI：1.43-3.13）；家庭和工作中被动吸烟与小于胎龄儿之间的关系均没有统计学意义。结论孕妇孕期被动吸烟可增加发生小于胎龄儿的危险性。除了家庭和工作环境外，还应注意其他环境的被动吸烟。Objective To study the association between maternal passive smoking during pregnancy and the small-for-gestational-age （SGA） infants and to analyze independent factors on duration, in different areas. Methods Totally, 8 retrospective studies published in PubMed （no year limited）, OVID-MEDL1NE （no year limited）, CNKI （from 1911 to 2008）, VIP （from 1989 to 2008）, and CBM （no year limited）, on maternal passive smoking during pregnancy and SGA were analyzed synthetically by Meta-analysis. Results The unadjusted pooled OR value on the association between matemal passive smoking during pregnancy and SGA was 1.45 （95%CI： 1.05-2.01）. Data showed that the adjusted pooled OR value was 1.76 （95%CI：1.15-2.69）. Maternal passive smoking in early pregnancy was a risk factor for SGA （OR=1.85, 95%CI： 1.25-2.72）, and so was the exposure in mid or late pregnancy （OR=2.12, 95%CI： 1.43-3.13）. No statistically significant relationship between SGA and passive smoking at home or at workplace was found. Conclusion Avoiding passive smoking in pregnancy for mothers could reduce the possibility of delivering SGA infants. Other than at home or at workplace, problem of passive smoking in other places should also be brought up.

关 键 词：被动吸烟 小于胎龄儿 META分析 

分 类 号：R173[医药卫生—妇幼卫生保健]