DNA-guided hepatitis B treatment,viral load is essential,but not sufficient  

作　　者：Rafael Bárcena Marugán Silvia García Garzón 

机构地区：[1]Services of Liver-Gastroenterology,Hospital Ramón y Cajal,University of Alcalá [2]Department of Gastroenterology,Hospital Universitario de Guadalajara,University of Alcalá

出　　处：《World Journal of Gastroenterology》2009年第4期423-430,共8页世界胃肠病学杂志（英文版）

摘　　要：Hepatitis B virus （HBV） infection is a global public health problem that concerns 350 million people worldwide. Individuals with chronic hepatitis B （CriB） are at increased risk of developing liver cirrhosis, hepatic de-compensation and hepatocellular carcinoma. To maintain undetectable viral load reduces chronic infection complications. There is no treatment that eradicates HBV infection. Current drugs are expensive, are associated with adverse events, and are of limited efficacy. Current guidelines try to standardize the clinical practice. Nevertheless, controversy remains about management of asymptomatic patients with CriB who are hepatitis B e antigen （HBeAg）-positive with normal alanine aminotransferase, and what is the cut-off value of viral load to distinguish HBeAg- negative CriB patients and inactive carriers. We discuss in detail why DNA level alone is not sufficient to begin treatment of CriB.Hepatitis B virus(HBV) infection is a global public health problem that concerns 350 million people worldwide.Individuals with chronic hepatitis B(CHB) are at increased risk of developing liver cirrhosis,hepaticde-compensation a nd hepatocellular carcinoma.To maintain undetectable viral load reduces chronic infection complications.There is no treatment that eradicates HBV infection.Current drugs are expensive,are associated with adverse events,and are of limited efficacy.Current guidelines try to standardize the clinical practice.Nevertheless,controversy remains about management of asymptomatic patients with CHB who are hepatitis B e antigen(HBeAg)-positive with normal alanine aminotransferase,and what is the cut-off value of viral load to distinguish HBeAg-negative CHB patients and inactive carriers.We discuss in detail why DNA level alone is not sufficient to begin treatment of CHB.

关 键 词：Hepatitis B virus Viral DNA Alaninetransaminase Antiviral drug Hepatitis B e antigen Antiviral drug resistance 

分 类 号：R512.62[医药卫生—内科学]