马尾藻多糖对小鼠免疫功能调节作用的研究  

Experimental Study of Sargassum Polysaccharide's Immune Modulatory Effect in Mice

作　　者：陈忠伟[1] 高建峰[2] 胡庭俊[3] 何颖[1] 刘伟[1] 胡帅[1] 赵武[1,1] 李斌[1] 梁家幸[1] 关忠谊[1] 

机构地区：[1]广西兽医研究所,南宁530001 [2]甘肃农业大学,兰州730070 [3]广西大学动物科技学院,南宁530004

出　　处：《中国畜牧兽医》2009年第1期57-59,共3页China Animal Husbandry & Veterinary Medicine

基　　金：广西科技攻关资助项目(桂科攻0630001-1D)

摘　　要：试验旨在观察马尾藻多糖(SP)对小鼠免疫调节的影响。用地塞米松作免疫抑制剂建立免疫功能低下动物模型,测定了小鼠胸腺指数和脾脏指数,血浆中溶菌酶含量和酸性磷酸酶(ACP)活力,胸腺和脾脏匀浆中总超氧化物歧化酶(SOD)、黄嘌呤氧化酶(XOD)、过氧化氢酶(CAT)、一氧化氮水平(NO)和丙二醛(MDA)含量。结果表明,马尾藻多糖能显著提高正常小鼠和免疫抑制小鼠的胸腺指数、血浆中溶菌酶含量、ACP活力和胸腺及脾脏中NO含量;显著提高免疫抑制小鼠脾脏CAT活力;增强正常小鼠脾脏总SOD活力;显著降低正常小鼠脾脏匀浆MDA含量;显著降低免疫抑制小鼠胸腺和脾脏匀浆中XOD活力。因此,马尾藻多糖能显著增强小鼠的免疫功能。To investigate the immune-regulatory effects of sargassum polysaccharide（SP） on mice. The immunosuppressed model in mice was induced by dexamethasone（Dex）. The TI, SI, lysozyme concentration and ACP, SOD, XOD, CAT, NO, MDA in thymus and spleen were analyzed to investigate the immune-regulatory effects of SP. The TI, SI, lysozyme concentration, ACP, NO was increased in normal and immunosuppressed mice following treated with SP. The CAT activity in immuno- suppressed mice and the SOD activity in normal mice was both enhanced by treatment of SP. Furthermore, the MDA concentration in spleen in normal mice and the XOD activity in thymus and spleen in immunosuppressed mice was also enhanced following treatment of SP. Therefor,the SP could improve the immune function of the mice.

关 键 词：马尾藻多糖 免疫抑制模型 免疫功能调节 

分 类 号：S852.4[农业科学—基础兽医学]