儿童过敏性紫癜与不同类型幽门螺杆菌感染的相关性  

Henoch-Schonlein purpura and different patterns of Helicobacter pylori infection in children

作　　者：高晓琳[1] 黄永坤[1] 刘梅[1] 李琪[1] 曾洁[1] 李海林[1] 

机构地区：[1]昆明医学院第一附属医院儿科,云南省昆明市650032

出　　处：《世界华人消化杂志》2009年第2期198-201,共4页World Chinese Journal of Digestology

基　　金：云南省中青年学术技术带头人后备人才培养计划资助项目;No.2006PY1-18~~

摘　　要：目的:探讨儿童过敏性紫癜(Henoch-Schonlein purpura,HSP)与不同类型幽门螺杆菌(Hpylori)感染的关系.方法:用免疫印迹法对80例HSP患儿及40例正常儿童的血清进行幽门螺杆菌分型检测.将80例HSP患儿分为有消化系症状HSP组(51例)和无消化系症状HSP组(29例).结果:有消化系症状HSP组患儿Ⅰ型Hpylori感染占25.5%,Ⅱ型Hpylori感染占52.9%;而无消化系症状HSP组和正常对照组均无Ⅰ型Hpylori感染,Ⅱ型Hpylori感染分别为34.5%、12.5%;三组的Hpylori抗体分型检出率有统计学意义(P<0.001).有消化系症状HSP组患儿的Hpylori抗体阳性检出率明显高于无消化系症状HSP组和正常对照组(78.4%vs34.5%,12.5%,P<0.001).结论:HSP的发病可能与Hpylori感染有关,其消化系症状与Ⅰ型Hpylori感染密切相关.免疫印迹技术可应用于对Hpylori感染分型诊断.AIM： To investigate the relationship between Henoch-Schonlein purpura （HSP） and different types of H pylori in children. METHODS： Western immunoblotting method was used to detect the serial antibodies of H pylori in 80 children with HSP and 40 normal healthy children. According to clinical manifestation, 80 children were divided into HSP group with gastrointestinal symptoms （51 cases） and HSP group without gastrointestinal symptoms （29 cases）. RESULTS： In HSP group with gastrointestinal symptoms, Ⅰ -H pylori infection accounted for 25.5%, and Ⅱ-H pylori infection accounted for 52.9%; however, there were no Ⅰ type H pylori infection in HSP group without gastrointestinal symptoms and normal control group. But 34.5% in HSP group without gastrointestinal symptoms and 12.5% in normal control group were infected with Ⅱ type H pylori; the distribution differences of H pylori antibody typing had statistical significance （P 〈 0.001）. H pylori antibody positive rate of HSP group with gastrointestinal symptoms was significantly higher than those of HSP group without gastrointestinal symptoms and of normal control group （78.4% vs 34.5%, 12.5%, P 〈 0.001）. CONCLUSION： The HSP incidence may be associated with H pylori infection, and the digestive tract symptoms is closely correlated with Ⅰ type infection. Western Immunoblotting technique can be applied to the diagnosis of of H pylori typing.

关 键 词：儿童 过敏性紫癜 幽门螺杆菌 免疫印迹法 

分 类 号：R725.5[医药卫生—儿科] R725.7[医药卫生—临床医学]