大鼠鼻粘膜及耳廓皮肤肥大细胞与肽能神经末梢关系的免疫组织化学研究  

AN IMMUNOHISTOCHEMICAL STUDY ON RELATIONSHIP BETWEEN MAST CELL AND PEPTIDERGIC TERMINAL IN NASAL MUCOSA AND AURICLE SKIN IN RAT

作　　者：赵长青[1] 王建亭[1] 陶正德[2] 肖健云[2] 赵素萍[2] 

机构地区：[1]山西医科大学第二医院耳鼻咽喉科,太原030001 [2]湖南医科大学附属湘雅医院耳鼻咽喉科

出　　处：《解剖学杂志》1998年第2期123-126,共4页Chinese Journal of Anatomy

摘　　要：目的:为了从形态学角度验证肥大细胞与肽能神经“双向”调节理论.方法:采用免疫组织化学方法(ABC法)对Wistar大鼠鼻粘膜及耳廓皮肤进行肥大细胞与肽能神经末梢关系的研究.结果:大鼠鼻粘膜及耳廓皮肤肥大细胞与P物质能神经末梢存在较为密切的形态学构筑关系;肥大细胞可“串连”于P物质能神经纤维;肥大细胞免疫组化染色呈阳性,但尚不能断定肥大细胞为P物质阳性细胞.结论:提示肥大细胞与P物质能神经关系密切,为进一步研究肥大细胞的非IgE调控机制提供了形态学依据.To further exploit the hypothesis of "bi-directional" regulation between mast cells (MC) and peptidergic terminals morphologically, an immunohistochemical study on the relation between MC and substance P(SP)-ergic terminal in nasal mucosa and auricle skin in rat was carried out. The results showed that (1) there were close morphological relations between the cell and the terminal; (2) MC was often "strung" on, or embraced by the terminal; and (3) MC was im-munologically "stained". These results provide a morphological basis for the theory of non-IgE regulation of mast cells.

关 键 词：肽能神经 鼻粘膜 耳廓皮肤 肥大细胞 形态学 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]