舒芬太尼用于胸外科开胸手术术后静脉镇痛的临床研究  

Clinical Study of Patient-controlled Intravenous Analgesia with Sufentanil After Thoracotomy

作　　者：张永昌[1] 张喜林[1] 

机构地区：[1]中国石油中心医院麻醉科,河北廊坊065000

出　　处：《实用预防医学》2009年第1期191-192,共2页Practical Preventive Medicine

摘　　要：目的研究舒芬太尼用于胸外科开胸手术后病人静脉自控镇痛(PCIA)的效果和不良反应。方法择期胸外科开胸手术患者60例,随机分为二组(n=30)。各组镇痛泵配制方法如下,实验组:舒芬太尼250μg+托烷司琼5mg/200 ml;对照组:芬太尼1.0 mg+托烷司琼5 mg/200 ml。观察记录术后4、8、12、24、36各时点镇痛评分(VAS)和镇静评分(SS)及其间的不良反应情况。结果两组镇痛评分(VAS)和镇静评分(SS)有显著的统计学差异(P<0.05),实验组的镇痛评分(VAS)和镇静评分(SS)明显低于对照组,实验组恶心呕吐不良反应明显低于对照组。结论舒芬太尼用于胸外科开胸手术术后静脉自控镇痛的镇痛效果优良,不良反应少,是一种更为安全、有效的镇痛方法。Objective To investigate the effect and safety of patient- controlled intravenous analgesia （PCIA） with sufentanyl on patients who underwent thoracotomy. Methods Sixty patients who underwent thoracotomy were randomly divided into experimental group （sufentanyl 2.50μg ＋ tropisetron 5 mg/200ml） and control group （fentanyl 1.0mg ＋ tropisetron 5mg/200ml）, （each n=30）. Visual analog scale score （VAS） and sedation score were recorded at 4, 8, 12, 24, and 36 hours after operation, side effects within 36 hours after operation were observed. Results There were significant differences in VAS scores and sedation scores between the patients of the two groups （P〈 0.05）. VAS scores, sedation scores, and side effects of nausea and vomiting of experimental group were all significantly less than those in control group （P 〈 0.05）. Conclusions Sufentanyl in patient - controlled intravenous analgesia possesses good effect of analgesia and less adverse reaction, it is a way of safer and more effective analgesia.

关 键 词：舒芬太尼 芬太尼 术后静脉镇痛 视觉模拟评分法 

分 类 号：R982[医药卫生—药品]