药物治疗后乙型肝炎病毒基因类型转化分析  

Analysis of Transformation of HBV Genotypes After Medicine Cure

作　　者：代国知[1] 陈亚光[1] 林应标[1] 李刚勇[1] 吴怀益[1] 

机构地区：[1]湖南省郴州市第一人民医院,湖南郴州423000

出　　处：《实用预防医学》2009年第1期253-254,共2页Practical Preventive Medicine

摘　　要：目的探讨乙型肝炎病毒药物治疗后基因类型转化情况。方法对2004年我院肝病门诊103例已作过乙型肝炎病毒基因分型的患者,分别进行拉米夫定和干扰素治疗,治疗停药一年后,复检乙型肝炎病毒基因类型。结果103例病人中,65例用拉米夫定治疗,29例用干扰素治疗,9例用其它核苷类药物治疗,停药后复查患者基因类型,除5例未分析出结果外,98例患者通过药物治疗基因类型均未改变。结论乙型肝炎病毒不管是否经过药物治疗,其基因类型在一定时期内是不会发生基因类型改变的。Objective To explore the transformation condition of HBV genotypes after the medicine cure. Methods A total of 103 outpatients who had taken the inspection of HBV genotypes were respectively administrated lamivudine and interferon in our hospital in 2004. Their HBV genotypes were redetermined one year after withdrawing therapy. Results Among the 103 patients, 65 patients received lamivudine, 29 patients received interferon, and 9 patients received other nucleoside analogues. The results of HBV genotype redetermination indicated that 98 patients＇ genotypes remained unchanged after the medicine treatment, and genotype analysis failed of success in 5 patients, Conclusion No matter whether the HBV patients receive therapy or not, their genotypes will not change in a certain time.

关 键 词：乙型肝炎病毒 基因型 基因转化 

分 类 号：R373.21[医药卫生—病原生物学]