磺胺甲噁唑在大菱鲆体内药代动力学及残留消除规律的研究  

Pharmacokinetics and Elimination of Sulfamethoxazole in Turbot

作　　者：曲志娜[1] 赵思俊[1] 王玉东[1] 路平[1] 李存金[1] 谭维泉[1] 孙晓亮[1] 郑增忍[1] 

机构地区：[1]中国动物卫生与流行病学中心,山东青岛266032

出　　处：《中国兽药杂志》2009年第2期28-31,共4页Chinese Journal of Veterinary Drug

摘　　要：采用高效液相色谱法,对以80 mg/kg b.w.单剂量口灌磺胺甲噁唑的大菱鲆进行连续采样监测,研究大菱鲆口服磺胺甲噁唑的药代动力学特征及残留消除规律。结果表明,磺胺甲噁唑在大菱鲆血液、肌肉中药代动力学特征分别符合带时滞的一级吸收二室开放模型、一级吸收一室开放模型。磺胺甲噁唑在大菱鲆体内消除速度较慢,16℃水温的实验条件下,在大菱鲆肌肉中的休药期为27天。The residue of SMZ in turbot which was exposured to 80 mg/kg b.w. SMZ solution was monitored continually by HPLC, and the pharmacokinetics and elimination of SMZ in turbot after oral administration were studied. The result showed that the concentration - time course of the drug conformed to the characteritics of the two compartment open model with the first order absorption and a e for the blood, and the one compartment open model with first order absorption and a lagtime for the muscle. SMZ was slowly eliminated in turbot. The concerntration of SMZ in the muscle was below LOD after 27days

关 键 词：磺胺甲噁唑 大菱鲆 药代动力学 消除 高效液相色谱法 

分 类 号：S948[农业科学—水产养殖]