雄黄水飞法炮制工艺探讨  

Study on Water Processing Conditions of Realgar

作　　者：姜泓[1] 丁敬华[1] 张颖花[1] 石松田[1] 高双[1] 宫慧芝[1] 孙贵范[1] 

机构地区：[1]中国医科大学公共卫生学院,辽宁沈阳110001

出　　处：《中药材》2009年第1期26-28,共3页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金资助(30530640)

摘　　要：目的:优选雄黄水飞炮制方法的最佳工艺条件。方法:以加水量、操作次数和干燥温度为因素水平,用L9(3)4正交设计对炮制条件进行优选。采用离子交换高效液相色谱-氢化物发生-原子荧光光度法测定雄黄中可溶性砷盐As(Ⅲ)的含量。结果:雄黄水飞的最佳炮制工艺为加15倍量水、操作8次、干燥温度40℃。结论:此法准确、可靠,为雄黄炮制品的制备工艺和质量评价提供了一定的科学依据。Objective： To optimize the water processing （shui-fei）condition of Realgar. Methods： The processing conditions were optimized by L9 （ 3 ） 4 orthogonal design with three factors as water dose, process times and dryness temperature. The content of dissolved arsenic As（ Ⅲ ） in Realgar was tested by High Performance Liquid Chromatography-hydride generation on-line coupled with atomic fluo- rescence spectrometry（HPLC-HG-AFS）. Results ：The optimized conditions were 15 times quantity of water, 8 times for processing and dryness temperature of 40℃. Conclusion ：The method is accurate and effective ,which can be used to evaluate the quality of processed products of Realgar.

关 键 词：雄黄 三氧化二砷 正交试验 

分 类 号：R283[医药卫生—中药学]