168株痢疾杆菌的菌群鉴定及药敏试验结果分析  

Distribution of 168 Shigella strains and results of drug sensitivity test

作　　者：栗绍刚[1] 李威[1] 阴赪宏[1] 郑晓燕[1] 

机构地区：[1]首都医科大学附属北京友谊医院热带医学研究所,北京100050

出　　处：《中国热带医学》2009年第3期514-515,共2页China Tropical Medicine

基　　金：北京市自然科学基金资助项目(7052026)

摘　　要：目的了解本地区腹泻患者检出痢疾杆菌菌群分布及对药物敏感情况。方法收集我院肠道门诊2006年6～10月腹泻患者粪便标本进行痢疾杆菌分离,以生化试验和血清学试验进行菌株鉴定分群,以K-B法进行药物敏感试验。结果共分离出168株痢疾杆菌,生化及血清鉴定结果,宋内志贺菌占63.7%,福氏志贺菌占35.1%,鲍氏志贺菌占1.2%,未检出痢疾志贺菌;药敏显示检出菌株对诺氟沙星、奥格门丁的耐药率分别为8.3%、9.5%,对磺胺、氨苄西林、四环素、萘啶酸、利福平有较高的耐药率均超过75%。结论宋内痢疾杆菌为优势菌群,检出菌株对诺氟沙星、奥格门丁的耐药率较低,可为临床使用抗生素提供参考。Objective To understand the distribution of Shigella and their antibiotic resistant characteristics in our hospital. Methods The stool samples of the patients with diarrhea were collected in Gastro-intestinal department of our hospital from June to October 2006. Then the bacteria were isolated, cultured and identified. Meanwhile antimicrobial susceptibility test was performed using K-B method. Results Of the 168 Shigella strains detected, S. sonnei, S. f lexneri, S.boydii. were accounted for 63.7%, 35.1% and 1.2%, and S. dysenteriae was not detected. The resistant rate of Shigella strains to norfloxacin and amoxicillin were 8.3% and 9.5%. The resistant rate to sulfasulfonamides , ampicillin ,ambramycin, nalidixie acid and rifampicin were all over 75%. Conclusion The main serotypes of Shigella spp is S. sonnei. The resistant rate of Shigella strains to norfloxacin and amoxicillin is low.

关 键 词：痢疾杆菌 菌群 药敏试验 耐药率 

分 类 号：R378.25[医药卫生—病原生物学]