P-选择素和胰岛素抵抗对糖尿病肾病的影响  

Effect of P-selectin and insulin resistance on diabetic Nephropathy.

作　　者：陈祥坤 盛春永[2] 

机构地区：[1]山东省武所屯生建煤矿医院内科 [2]山东省滕州市中心人民医院核医学科,山东滕州277500

出　　处：《临床和实验医学杂志》2009年第2期5-6,共2页Journal of Clinical and Experimental Medicine

摘　　要：目的研究P-选择素、胰岛素抵抗(IR)与糖尿病肾病(DN)的关系。方法对109例2型糖尿病(T2DM)患者(有肾病者为DN组、无肾病者为DM组)和正常对照组(NC),进行空腹血糖(FPG)、胰岛素、P-选择素测定,计算HOMA法胰岛素抵抗指数(HOMA-IR)。结果DN和DM组血中的FPG、胰岛素、P-选择素及HOMA-IR均高于NC组(P<0.01),且DN组上述结果都高于DM组(P<0.01),相关分析表明IR与P-选择素呈正相关,多元回归显示DN发生与高FPG、高胰岛素、IR及P-选择素相关。结论P-选择素参与了IR,且P-选择素与IR一起参与了T2DM患者DN的发生、发展过程。Objective To study the association between P-selectin,insulin resistance（IR） and diabetic nephropathy（DN）. Methods Fresh plasma glucose（FPG）、insulin and P-seleetin were detected in 109 cases with type 2 diabetes mellitus（T2DM） ,which were seperated into groups ： Group DN, with nephropathy ; group DM, without nephropathy and normal control, then calculate the value of HOMA-IR. Results FPG、insulin、P-selectin and HOMA-IR in group DN and DM were remarkably higher than that in normal controls（ P 〈0.01 ） ,and the results above in Group DN were higher than that in Group DM （ P 〈0.01 ）. Related analysis showed that IR had positive correlation with P-selectin, multiple linear regression displayed that DN genesis had association with high FPG, hyper insulin, IR and P-selectin. Conclusion P-selectin has participate IR and together with IR participate the course of DN＇s genesis and development in T2DM.

关 键 词：2型糖尿病 胰岛素抵抗 P-选择素 

分 类 号：R587.2[医药卫生—内分泌] R692[医药卫生—内科学]