女性腰椎侧位与后前位骨密度的相关性研究  

Correlations of lateral position and posyertoanterior lumbar bone mineral density in female

作　　者：郭郡浩[1] 赵智明[1] 姚茹冰[1] 董晓蕾[1] 金洁[2] 蔡辉[1] 

机构地区：[1]南京军区南京总医院,中西医结合科210002 [2]南京军区南京总医院博士后工作站,江苏南京210002

出　　处：《实用临床医药杂志》2009年第1期47-51,共5页Journal of Clinical Medicine in Practice

基　　金：江苏省"六大人才高峰"资助项目(2005A3);南京军区南京总医院科研基金项目(2006029)

摘　　要：目的分析女性腰椎侧位与后前位骨密度（BMD）的相关性，探索女性腰椎骨密度的变化规律。方法观察166名45～70岁的女性无骨质疏松症状健康体检者，使用GE Lunar Prodigy型双能骨密度仪测量观察对象的腰椎后前位BMD（L2-4 BMD）、侧位BMD（B2-4 BMD），根据是否绝经及L2-4BMD是否正常，将观察对象分为4组，即未绝经L2-4BMD正常组、未绝经L2-4BMD异常组、绝经后L2-4BMD正常组、绝经后L2-4BMD异常组，分析L2-4BMD、B2-4BMD及其与年龄、体质量指数等的相关关系，并建立回归方程。结果在L2-4BMD正常组，绝经者BMD与未绝经者比较有显著差异，绝经后BMD明显降低；在L2-4BMD异常组，绝经者BMD与未绝经者比较，L2-4BMD明显降低，L2-4BMD无显著差异。各组B2—4BMD与L2-4BMD均具有显著相关关系。绝经后L2-4BMD正常组B2-4BMD与绝经年数的相关有显著统计学意义。多元回归分析显示，因变量B2-4BMD（Y）主要由L2-4BMD（X1）、绝经年数（X2）、体质量指数（X3）决定，各组具有相应的回归模型：绝经后L2-4BMD正常组、绝经后L2-4BMD异常组、未绝经L2-4BMD正常组、未绝经L2-4BMD异常组，其B2-4BMD的回归方程分别为：r=0．147＋0．501 X1-0．007 Xz，y=-0．437＋0．457 X1＋0．024 X3，Y=0．102＋0．559 X1，Y=-0．350＋0．947 X1。结论女性B2-4BMD与L2-4BMD有显著相关关系；女性B2-4BMD与是否绝经、L2-4BMD是否正常有关，绝经后女性更应当早期检查骨密度。Objective To analyze the dependability of lateral position and P - A position lumbar bone mineral density（BMD） in female and to explore variation regularity of female＇s lumbar vertebra BMI）. Methods 166（45 yr-70 yr） healthy females were selected, whose P- A position BMD（L2-4BMI）） and lateral position BMD （132-4BMD）were measured by GE Lunar Prodigy dual energy X-ray absorptiometry. Observed objects were divided into 4 groups, pre-menopausal group with normal L2-4BMD, postmenopausal group with abnormal 14-4BMD, post-menopausal group with normal L2-4BMD and post-menopausal group with abnormal L2-4BMD, to analyze the correlations of L2-4BMD, B2-4BMD, years of age and body mass index. Regression equation was then established. Results In the L2-4BMD normal groups, there was significant deviation between pre-menopausal group and post-menopause group and BMD in the post-menopause group decreased rapidly. In the L2-4 BMD abnormal groups, significant deviation between premenopausal group and post- menopausal group was observed. Compared with L2-4 BMD pre-menopausal group, L2-4BMD in post -menopausal group was significantly decreased while B2-4BMD was not. There were clear-cut correlations between B2-4BMD and L2-4BMD in each group. B2-4BMD in post-menopausal group with normal L2-4 BMD was correlated significantly with years of menopause. Multiple regression analysis showed that dependent variable B2-4 BMD （ y ） was mainly determined by L2-4 BMD （ X1 ） , years of menopause （ X2 ） and BMI （ X3 ） . Regression equation of each of the 4 groups was ： y = 0. 1 4 7 ＋ 0. 501X1-0.007X2,y =-0.437＋ 0.457X1 ＋ 0.024X3,y=0. 102＋ 0. 559Xl,y =-0. 350 ＋ 0. 947 X1. Conclusion Clear-cut correlations exist between B2-4BMD and L2-4BMD in female. B2-4BMD in female is related to L2-4BMD. Females of post-menopause should check BMD as soon as they can.

关 键 词：骨质疏松症 骨密度 女性 

分 类 号：R589.5[医药卫生—内分泌]