异黄酮对女性健康作用的研究进展  

Advances in study about effects of isoflavones on women health

作　　者：陆晓和[1] 金念祖[2] 

机构地区：[1]南京军区南京总医院药学部,南京210002 [2]南京医科大学公共卫生学院,南京210029

出　　处：《药学与临床研究》2009年第1期47-50,共4页Pharmaceutical and Clinical Research

基　　金：国家自然科学基金资助项目(批准号:30572133)

摘　　要：异黄酮是最常见的一类植物雌激素,它们能与体内的雌激素受体选择性结合,并在相应的靶组织产生与雌激素相似的活性作用。早期的流行病学调查发现,中国和其它亚洲国家妇女乳腺癌的发病率低与其大豆摄入量高有关,由此引发了人们对异黄酮的广泛关注。许多研究结果表明,异黄酮可以预防或减轻更年期妇女的心血管疾病、骨质疏松症以及潮热、盗汗等血管舒缩症状,但也有一些研究结果并未观察到这些作用。异黄酮对妇女乳腺癌预防作用的研究结果至今仍然是相互矛盾或不确定的。鉴于异黄酮对妇女健康作用的研究结果尚不一致,不建议更年期妇女服用含有异黄酮或其它植物雌激素的制剂。Isoflavones are a kind of most familiar phytoestrogen. It can selectively bind to the estrogen receptor, mimicking the effects of estrogen. Interest in isoflavones has been fueled by early epidemiologic studies that have suggested low incidence of breast cancer in Asian countries with high soy intake. It has been found that isoflavones may have a protective effect on the cardiovascular system, reduce menopausal symptoms such as osteoporosis and hot flash when applied during early postmenopause, but some researches did not find these effects. Data regarding the role of isoflavones in breast cancer prevention is also conflicting. Inasmuch as the effects of isoflavones on women health remain contradictory and inconclusive, patients with menopausal symptoms should not be advised to take preparations containing isoflavones or other phytoestrogens.

关 键 词：异黄酮 乳腺癌 骨质疏松症 心血管疾病 更年期症状 

分 类 号：R285[医药卫生—中药学] R737.9[医药卫生—中医学]