秀丽隐杆线虫抗性基因研究进展  

Research Development of Resistance Genes in Caenorhabditis elegans

作　　者：陈星桃[1,2] 王桂堂[1] 

机构地区：[1]中国科学院水生生物研究所／淡水生态与生物技术国家重点实验室,武汉430072 [2]中国科学院研究生院,北京100039

出　　处：《华中农业大学学报》2008年第6期811-819,共9页Journal of Huazhong Agricultural University

基　　金：湖北省科技攻关项目(2007AA203A01)资助

摘　　要：从3个方面总结了秀丽隐杆线虫在抗性基因方面的研究进展。秀丽隐杆线虫的先天性免疫系统在抗病原菌、抗氧化应激等方面至关重要,它主要是通过MAPK、DAF-2、TGF-β三条信号途径发挥作用;另外,含TIR区蛋白和抗菌多肽也是秀丽隐杆线虫抗微生物感染机制的重要组成部分。在秀丽隐杆线虫的抗药性基因研究方面,发现了许多抗药性相关蛋白,如P-糖蛋白和多药耐药性相关蛋白MRP在抵抗多种药物的过程中发挥重要作用;而抗驱虫剂相关蛋白也在专门针对各种驱虫剂作用机制的研究中被发现;转录因子SKN-1、信息沉默调节蛋白SIR2、谷胱甘肽转移酶等在抗百草枯等药物方面发挥着重要作用;研究还发现遍在蛋白Phb-2等对特定药物起抗性作用。此外,本文还对抗环境刺激涉及的基因、蛋白及信号途径进行了简单叙述。Research development of the resistance genes in Caenorhabditis elegans is reviewed in this paper from the following three aspects. First of all, the innate immunity of C. elegans, which has been found to carry out mainly through the three signaling pathways, i. e. MAPK, DAF-2 and TGF-β, plays a significant role in anti-pathogenic bacteria and anti-oxidative stress, etc. Besides, the TIR domain contained proteins and anti-microbial peptides are also important components in the anti-pathogenic bacterium mechanism of the C. elegans. Secondly, a lot of anti-drug correlated proteins have been discovered in C. elegans while studying the mechanism of drug resistance. For example, P-glycoprotein and multidrug resistance associated proteins play an important part in defending different drugs. In addition, anti- anthelmintic relating proteins have also been discovered in the study of the anthelmintic mechanism. It is found that the transcription factor SKN-1, silent information regulator 2 and glutathione s-transferase work in defending kinds of drugs such as the parquet, while the ubiquitin 2 play a role in anti-special drugs. Finally, this paper makes a simple description about the discoveries in the genes, proteins and signal pathways of C. elegans in relation to anti-environmental stress.

关 键 词：秀丽隐杆线虫 抗性 信号途径 应激 

分 类 号：S917.4[农业科学—水产科学]