胆囊结石患者手术前后红细胞免疫功能研究  

Immune function of red blood cells in the patients with cholecystolithiasis before and after operation

作　　者：程敏[1] 王竹平[1] 张英民[1] 

机构地区：[1]湖北医科大学附属第一医院普外科,武汉430060

出　　处：《中华实验外科杂志》1998年第1期36-37,共2页Chinese Journal of Experimental Surgery

摘　　要：目的探讨胆囊结石患者红细胞免疫功能状况,借以评估其病情转化和预后。方法对30例胆囊结石患者手术前后外周血红细胞免疫功能采用酵母菌花环法进行动态检测。结果胆囊结石患者与健康人相比,红细胞C_3b受体花环率(RBC-C_3bRR)下降(P<0.05);红细胞免疫复合物花环率(RICR)升高(P<0.05);红细胞免疫粘附促进因子百分率(RFER)下降(P<0.01);抑制因子百分率(RFIR)升高(P<0.01)。术后第1天与术前比较,上述指标变化更为明显。术后第4天及7天RBC-C_3bRR、RFER逐步增高,RICR、RFIR则逐步下降。结论胆囊结石患者存在着继发性红细胞免疫功能降低,对感染易感性增高,常易伴发急性或慢性胆囊炎。Objective To investigate the immune function of red blood cells (RBC) in the patients with chole- cystolithiasis to evaluate the patients' conditions and prognosis. Methods The immune function of RBC of the peripheral blood in 30 cases was dynamically detected with yeast rosette method before and after the operation. Results The RBC C_3b receptor rosette rate (RBC-C_3bRR) and RFER were lower (P< 0.05, P<0.01), and RBC immunocomplex rosette rate (RICR) and RFIR higher (P<0.05, P< 0.01) in the patients with cholecystolithiasis than those in the control group. These parameters changed more obviously on the first postoperative day. RBC-C_3bRR and RFER were gradually increased, and RI- CR and RFIR decreased on the 4th or 7th postoperative days. Conclusion The patients with cholecys- tolithiasis have secondary RBC immune dysfunction which causes a high susceptibility to infection and are usually easy to accompany with acute or chronic cholecystitis.

关 键 词：胆囊结石 红细胞免疫功能 手术前 手术后 

分 类 号：R657.42[医药卫生—外科学]