复肝宁对实验性肝纤维化大鼠血清标志物和肝组织病理形态学的影响  

The Effects of Fuganning on Serum Indicators and Hepatic Tissue Pathological Changes in Rats with Hepatic Fibrosis

作　　者：梁治学[1,2] 胡燕[1] 周语平[3] 

机构地区：[1]平凉医学高等专科学校,甘肃平凉744000 [2]上海中医药大学,上海201203 [3]甘肃中医学院,甘肃兰州730000

出　　处：《中国实验方剂学杂志》2009年第2期71-73,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：甘肃省科学事业费资助科研项目(QS022-C33-007)

摘　　要：目的:观察中药复肝宁对实验性肝纤维化的预防效果,探讨其作用机理。方法:采用猪血清腹腔注射法造成大鼠免疫性肝纤维化模型,观察复肝宁对实验性肝纤维化大鼠肝纤维化血清标志物透明质酸(HA)、层粘连蛋白(LN)、Ⅳ型胶原(CIV)含量及病理形态学的影响。结果:肝纤维化大鼠在应用复肝宁后,血清HA,LN,CIV含量明显降低,肝组织病理损害明显减轻,胶原纤维明显减少,肝细胞坏死明显减轻,与病理模型组比较有显著性差异(P<0.05)。结论:复肝宁能有效地防止免疫性肝纤维化模型大鼠血清HA,LN,CIV含量的升高,减轻肝组织病理损害,可抑制肝纤维化形成,促进胶原降解,从而对肝纤维化具有一定的预防作用。Objective： To research the preventive effects and mechanism of Fuganning（FGN） on rats with hepatic fibrosis. Methods： Adopting intraperitoneal injection of porcine observed the effect of FGN onHA, LN, CIV and the pathological serum to induce rat immuno hepatic fibrosis model, chages of hepatic tissue. Results： The level of HA, LN, CIV were low, the pathological chages and the collagen fibresis decreased significantly in FGN group, this groups has significanc difference compare to model group （ P 〈 0. 05）. Conclusions ： In the experiment with hepatic fibresis rats, FGN can reduce the level of HA, LN, CIV. It can affect the collagen protein metabolism. Thus FGN prescription have effect on preventing hepatic fibresis.

关 键 词：复肝宁 肝纤维化 血清标志物 病理形态学 

分 类 号：R285.5[医药卫生—中药学]