胃选择性迷走神经切断对大鼠部分肝切除术后残肝再生的影响  

Effects of gastric selective vagotomy on residual liver regeneration after partial hepatectomy in rats

作　　者：陈剑英 夏清华[2] 陈汉顶 刘文根 

机构地区：[1]湖北省财贸医院普外科,武汉430015 [2]同济医科大学附属协和医院普外科

出　　处：《中华实验外科杂志》1998年第1期68-69,共2页Chinese Journal of Experimental Surgery

摘　　要：目的探讨胃选择性迷走神经切断术对肝再生的影响。方法建立肝部分切除术及加胃选择性迷走神经切断术两组动物模型,检测术后7天大鼠血清胃泌素、谷丙转氨酶、碱性磷酸酶、总胆红素、白蛋白水平,并观察残肝再生率、再生肝与体重比值及肝细胞有丝分裂指数的变化。结果胃选择性迷走神经切断术可使血清胃泌素、残肝再生率、再生肝重与体重比值、肝细胞有丝分裂指数升高,对肝功能无明显损害。结论胃选择性迷走神经切断术可促进肝再生,其原因可能为胃泌素升高所致。Objective To evaluate the effects of gastric selective vagotomy (GSV) on residual liver regeneration after partial hepatectomy in rats. Methods Two groups of rats randomly underwent either partial hepate- ctomy or partial hepatectomy plus GSV. The changes of the hereunder indexes were determined 7 days af- ter the operation: serum gastrin (SG), ALT, ALP, total bilirin, serum albumin, residual liver regeneration rate (LRR), the ratio of regenerated liver mass to body weight (RLM/BW) and the hepatocyte mitotic index (HMI). Results The SG level, LRR, RLM/ BW and HMI were significantly increased after GSV. No obvious deterious effects on liver function were found. Conclusion GSV can potentially promote the residual liver regeneration after partial hepatectomy, which resulted from the increase of SG level.

关 键 词：迷走神经切断 部分切除 肝再生 肝切除 

分 类 号：R657.305[医药卫生—外科学]