中药外贴对强直性脊柱炎患者微炎症状态的影响  

Effects of Herbal Plaster on Micro-inflammatory State in Patients with Ankylosing Spondylitis

作　　者：李桂 王晓军 钮含春 马振坤 李晓云 张红珊 

机构地区：[1]河北省石家庄平安医院风湿免疫科,河北石家庄050021

出　　处：《上海中医药大学学报》2009年第1期29-32,共4页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：河北省中医药管理局资助项目(2006142)

摘　　要：目的:研究强直性脊柱炎(AS)患者血清微炎症状态指标水平的变化及中药外贴双侧华佗夹脊穴的干预作用以探讨其作用机制。方法:将128例AS患者随机分为治疗组(66例)和对照组(62例);对照组给予柳氮磺胺吡啶和双侧华佗夹脊穴激光点灼,治疗组在对照组的基础上加用中药外贴双侧华佗夹脊穴。采用全自动酶联免疫分析仪检测血清TNF-α、IL-6、IL-8的水平,乳胶增强免疫比浊法检测CRP的水平;分析HLA-B27阳性和阴性的AS患者血清微炎症状态水平和中药外贴对其的干预作用。结果:AS患者血液微炎症状态指标CRP、IL-6、IL-8、TNF-α的水平较健康人明显升高(P<0.05),且HLA-B27阳性患者血液微炎症状态指标水平较HLA-B27阴性显著为高(P<0.05);经2个疗程治疗后,两组患者CRP、IL-6、IL-8、FNF-α的水平有明显下降(P<0.05或P<0.01),且治疗组较对照组明显(P<0.05或P<0.01)。结论:AS患者处于微炎症状态,血液存在高水平的CRP、IL-6、IL-8、TNF-α;HLA-B27阳性患者炎症病理损伤程度要大于HLA-B27阴性患者;中药外贴法能消除AS患者炎性因子IL-6、IL-8、TNF-α的刺激,抑制CRP的释放,从而改善其微炎症状态。Objective ： To observe the levels of micro-inflammatory indexes and effects of herbal piaster on micro-inflammatory state in patients with ankylosing spondylitis（AS） to explore its mechanisms. Methods： A total of 128 subjects were randomized into two groups： control group in which 62 cases were administered the Sulfasalazine and laser burning at Huatuo-jiaji acupoints, and treatment group in which 66 cases were treated with herbal plaster at Huatuo-jiaji acupoints besides the treatments in control group. Full-automatic enzyme immunodetection assay was employed to detect the levels of IL-6, IL-8, and TNF-α, and latex enhanced immuno-turbidimetry to detect the level of CRP; the micro-inflammatory state was compared between AS patients with positive and negative HLA-B27. Results： The levels of CRP, IL45, IL-8 and TNF-α in AS patients increased obviously（P 〈 0.05 ） ; the micro-inflammatory state was higher in AS patients with positive than those with negative HLA-B27 （P 〈 0.05 ） ; after two-course treatments, The levels of CRP, IL-6, IL-8 and TNF-α decreased（P 〈 0.05, P 〈 0.01 ） , with more significant reduction in treatment group than in control group（P 〈0.05, P 〈0.01 ）. Conclusion： Patients with ankylosing spondylitis are in micro-inflammatory state, with increased levels of CRP, IL-6, 1L-8 and TNF-α ; HLA-B27 positive patients have more severe pathological impairment than those with negative HLA-B27 patients; herbal plaster can obviously eliminate irritation of IL-6, IL-8 and TNF-ct, and suppress the release of CRP to improve micro-inflammatory state.

关 键 词：强直性脊柱炎 微炎症状态 华佗夹脊穴 外治法 

分 类 号：R244.9[医药卫生—针灸推拿学]