可调脉宽倍频Nd:YAG激光干预兔耳增生性瘢痕的实验研究  

A Experimental Study on Variable Pulse Frequency Doubled Nd:YAG Laser Treatment of Rabbit Ears Hypertrophic Scars

作　　者：谭军[1] 吴东辉[1] 张刚[1] 

机构地区：[1]湖南师范大学第一附属医院整形激光美容科,湖南长沙410005

出　　处：《激光生物学报》2009年第1期67-70,共4页Acta Laser Biology Sinica

基　　金：湖南省仁术基金项目(0513)

摘　　要：目的:探讨可调脉宽倍频Nd:YAG激光对兔耳增生性瘢痕的治疗作用。方法:制作兔耳增生性瘢痕模型,术后30天对兔耳增生性瘢痕进行可调脉宽倍频Nd:YAG激光干预,观察兔耳瘢痕大体形态和组织病理改变,并采用免疫组化的方法检测兔耳瘢痕治疗前后血管内皮生长因子(vascular endothelial growth factor,VEGF)的表达情况。结果:可调脉宽倍频Nd:YAG激光干预后,兔耳增生性瘢痕出现明显的萎缩,免疫组化检查VEGF表达减弱。结论:可调脉宽倍频Nd:YAG激光可能通过损伤瘢痕组织内的微血管促进兔耳增生性瘢痕萎缩,对早期增生性瘢痕具有治疗作用。Objective： To explore the treatment effect of variable pulsed frequency doubled Nd ： YAG laser on the hypertrophic scars of rabbit ears. Methods： Rabbit ear models of hypertrophic scars were built. On the 30th day after injury, the rabbit ear scars were treated with variable pulsed frequency doubled Nd：YAG Laser, the scars were observed morphologically and histologically. The vascular endothelial growth factor （VEGF） expression was detected with immunohistochemistry. Results： After treatment, the rabbit ear hypertrophic scars were noticeablly shrinked, and the VEGF expression decreased significantly. Conclusions： Variable pulsed frequency doubled Nd：YAG laser may destroy the microvessels and promote scars shrink. It provides a treatment option for early hypertrophic scar.

关 键 词：可调脉宽倍频Nd:YAG激光 瘢痕 兔 

分 类 号：Q631[生物学—生物物理学] R622[医药卫生—整形外科]