酒精摄入量与心血管病危险因子的相关性研究  

Relationship between alcohol consumption and risk factors for cardiovascular disease

作　　者：谭亚君[1] 陈瑜[1] 金胜航[1] 楼滨[1] 张杰[1] 范剑[1] 叶波[1] 

机构地区：[1]浙江大学医学院附属第一医院,浙江杭州310003

出　　处：《浙江大学学报（医学版）》2009年第1期89-94,共6页Journal of Zhejiang University(Medical Sciences)

摘　　要：目的:研究酒精摄入量与心血管病危险因子吸烟、血压、谷氨酰转肽酶(GGT)、缺糖基转铁蛋白百分比(%CDT)、超敏C反应蛋白(hs-CRP)、血同型半胱氨酸(HCY)、血脂的相关性。方法:将226例研究对象分成轻度、中度、重度饮酒和不饮酒4组,分别检测GGT、%CDT、hs-CRP、HCY等指标。结果:重度饮酒者吸烟比例明显高于其余各组(均P<0.05),且患高血压的比率也明显高于其余各组(均P<0.05)。重度饮酒者GGT明显高于其余各组(均P<0.05),且随着酒精摄入量的增加而升高;重度饮酒者的%CDT明显高于不饮酒者(P<0.05),重度饮酒者hs-CRP明显高于轻度饮酒和中度饮酒者(P<0.05),而中度饮酒者的hs-CRP明显低于不饮酒者(P<0.05);中度饮酒者和轻度饮酒者TG、LDL-C明显低于不饮酒者(P<0.05);各组间的HCY、CHOL、WBC、HDL-C、MCV均无明显差异(均P>0.05)。结论:重度饮酒与GGT、%CDT和hs-CRP的升高有关,其可能与其他心血管病危险因素如吸烟、高血压等共同作用增加患心血管疾病的危险性;少到中量饮酒者与低水平的hs-CRP有关,这可能通过抗炎作用对心血管系统有一定的保护作用。Objective： To investigate the relationship between alcohol consumption and risk factors for cardiovascular disease. Methods： Two hundreds and twenty six subjects were enrolled in the study and grouped to non-drinkers, mild drinkers, moderate drinkers and heavy drinkers. Serum GGT, hs-CRP,%CDT, HCY, lipoprotein were measured in all groups. Results： There were significantly higher GGT levels with heavy drinkers than those with other groups （P〈0.05） ,and GGT levels were increased with increasing alcohol intake; and there were significantly higher %CDT levels with heavy drinkers compared with those with no-drinkers; there was significant higher bs-CRP levels with heavy drinkers compared with those with mild and moderate drinkers （P〈0.05） ; but in moderate drinkers there was significantly lower hs CRP levels than non drinkers （P〈0.05）. Compared with non-drinkers,there were significantly lower LDL-C and TG levels with mild and moderate drinkers. There were no significant differences in CHOL, HDL-C,HCY,WBC,MCV levels among all groups. Heavy drinkers had higher smoking rate and higher prevalence of hypertension （P〈0.05）. Conclusions： Heavy alcohol consumption results in increasing GGT, %CDT and hs-CRP and may increase cardiovascular disease risk along with other risk factors. Mild to moderate alcoho tration,which may protect the cardiovascu consumption is associated with lower hs-CRP concenar system through anti-inflammatory mechanism.

关 键 词：心血管疾病 乙醇/代谢 饮酒 γ-谷氨酰转移酶/血液 半胱氨酸/血液 C反应蛋白质/血液 缺糖基转铁蛋白/血液 

分 类 号：R54[医药卫生—心血管疾病]