糖尿病足中终末糖基化产物表达与中医辨证分型及部位的相关性  

Associativity between TCM Syndrome Differentiation and Pattern Types for Diabetic Foot and Expression of Advanced Glycosylation Endoproducts

作　　者：代阿秋[1] 张庚扬[2] 李晓军[1] 常柏[3] 

机构地区：[1]天津中医药大学,2006级硕士研究生天津100193 [2]天津中医药大学第一附属医院 [3]天津医科大学代谢病医院

出　　处：《中国中西医结合外科杂志》2009年第1期7-9,共3页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金资助项目(30472117)

摘　　要：目的:研究糖尿病足截肢标本上动脉内终末糖基化产物(AGEs)的表达与糖尿病足中医辨证分型的相关性。方法:100例患者分为气血两虚瘀阻证、气阴两虚瘀阻证、脉络热毒证,对三型进行动脉AGEs的免疫组化研究。结果:在动脉中脉络热毒证表达最弱,气血两虚瘀阻证表达最强。各证型之间AGEs表达具有显著性差异(P<0.01)。结论:糖尿病足中医辨证分型与AGEs的表达具有较高的相关性。Objective diabetic foot and expression hundred cases with diabetic To investigate the associativity between TCM syndrome differentiation and pattern types for of advanced glycosylation endoproducts（AGEs） in arteries of amputation. Methods One foot were divided into stagnant deficiency of both Qi and blood type, stagnant deficiency of both Qi and Yin type and heat toxin in collaterals type according to syndrome differentiation in TCM. The studying of the expression of AGEs in artery was with immunohistoche- mistry method. Results The expression of AGEs was highest in stagnant deficiency of both Qi and blood type and lowest in heat toxin in collaterals type. There were significant differences for expression of AGEs among the three types（ P 〈 0. 01 ）. Conclusion There is high associativity between TCM syndrome differentiation and pattern types for diabetic foot and expression of AGEs.

关 键 词：糖尿病足 辨证 终末糖基化产物 

分 类 号：R587.2[医药卫生—内分泌] R241[医药卫生—内科学]