ER、PR、p53、c-erbB-2在乳腺囊性增生病中的表达意义  

Significance of Expression of ER,PR,p53 and C-erbB-2 in Breast Cystic Hyperplasia

作　　者：吴兴荣 骆利康[2] 陈震宏 张同义 申华峰[2] 徐文兴[2] 李娟梅[2] 龚庆琳 

机构地区：[1]浙江省衢州市中医医院普外科,衢州324002 [2]浙江省衢州市人民医院病理科 [3]浙江省衢州市妇幼保健院病理科

出　　处：《中国中西医结合外科杂志》2009年第1期27-28,共2页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

摘　　要：目的:研究乳腺囊性增生病中雌激素受体(ER)、孕激素受体(PR)、p53和c-erbB-2表达的临床意义。方法:用免疫组化SP法检测62例乳腺囊性增生病中ER、PR、p53和c-erbB-2表达分布情况。结果:62例患者中ER阴性6例,占10%;阳性56例,占90%。PR阴性7例,占11%;阳性55例,占89%。p53阴性35例,占57%;阳性27例,占43%。c-erbB-2阴性41例,占66%;阳性21例,占34%。结论:乳腺囊性增生病的发生与ER、PR有关,其病变发展与c-erbB-2和p53关系密切,同时也是检测是否癌变的一种实用可靠的方法。Objective To investigate the clinic significance of the expression of estrogen recepfor（ER）, progesterone recepfor（PR）, p53 and C - erbB - 2 in breast cystic hyperplasia. Methods The immunohistochemical SP method was applied to detect the expression of ER, PR, p53 and C - erbB - 2 in 62 cases of breast cystic hyperplasia. Results The positive rate of ER expression in 62 cases was 90%. The positive rate of PR expression was 89%. The positive rate of p53 and C - erbB - 2 expression was 43% and 34% respectively. Conclusion The origin of the breast cystic hyperplasia is relevant with ER and PR, and the development of the disease is also related with p53 and C - erbB - 2. As a result, the detection of these proteins is useful in the determination Of malignant change.

关 键 词：乳腺 囊性增生 雌孕激素受体 癌基因 免疫组化 

分 类 号：R655.8[医药卫生—外科学]