藤茶蛇葡萄素对人卵巢癌细胞和人恶性黑色素瘤细胞增殖的抑制作用  

Inhibitory Effect of Ampelopsis on Proliferation of Human Ovarian Cancer Cells and Malignant Melanoma Cells

作　　者：郑作文[1] 谭为[1] 周雅君[1] 毛健[1] 

机构地区：[1]广西中医学院,南宁市明秀东路179号530001

出　　处：《广西中医药》2009年第1期46-48,共3页Guangxi Journal of Traditional Chinese Medicine

基　　金：广西自然科学基金(桂科基0639052)

摘　　要：目的:探讨藤茶蛇葡萄素(APS)的体外抗肿瘤作用。方法:采用MTT法观察APS对人卵巢癌细胞SK-OV-3和人恶性黑色素瘤A375细胞抑制作用。结果:APS能明显抑制体外培养的SK-OV-3、A375细胞的生长。MTT结果显示,APS对SK-OV-3细胞的IC50为24.24μg/ml;对A375细胞的IC50为18.29μg/ml。结论:APS对体外SK-OV-3、A375细胞的生长均有明显的抑制作用。Objective： To study the in vitro anti-tumor effect of ampelopsis （APS）. Methods： The inhibitory effect of APS on the human ovarian cancer cell SK-OV-3 and human malignant melanoma cell A375 was observed using MTT. Results ： The growth of SK-OV-3 and A375 cultured in vitro was inhibited significantly by APS. The result of MTT showed that the IC50 of APS for SK-OV-3 and A375 was 24.24 μg/ml and 18.29 μg/ml, respectively. Conclusions： APS may significantly inhibit the growth of SK-OV-3 and A375 cell＇ s in vitro.

关 键 词：藤茶蛇葡萄素 抗肿瘤 SK—OV-3细胞 A375细胞 

分 类 号：R285.5[医药卫生—中药学]