脑活肽的 ^(125)I 标记及其在动物体内的生物分布  

STUDY ON 125 I LABELING OF CEREBROLYSIN AND ITS BIODISTRIBUTION IN MOUSE

作　　者：阎平[1,2] 倪秀雄[1,2] 林岷 王中洲[1,2] 黄庆忠[1,2] 卓若[1,2] 

机构地区：[1]福建医科大学核医学教研室 [2]福建医科大学病生教研室

出　　处：《同位素》1998年第1期44-47,共4页Journal of Isotopes

摘　　要：采用氯胺Ｔ法进行脑活肽的１２５Ｉ标记，标记率为（３２．５±５．０）％（ｎ＝３），标记产物比活度为１．９８ＴＢｑ／ｇ。２０％三氯乙酸沉淀法测定１２５Ｉ－脑活肽放化纯度＞９０％，１周内其放化纯度下降＜５％。１２５Ｉ标记脑活肽大白鼠体内生物分布结果表明，脑活肽能够通过血脑屏障，且在脑组织中的停留时间相对比其他组织长，说明脑组织具有一定的摄取１２５Ｉ－脑活肽的功能。Cerebrolysin is labeled with 125 I using the method of Chloramine T. The labelled yield is (32.5±5.0)% ( n =3) and the specific activity of the labeling product is 1.98 TBq/g. By the method 20% trichloroacetic acid precipitation, the radiochemical purity of the purified 125 I cerebrolysin is more than 90% and descent of radiochemical purity in a week is less than 5%. The results of biodistribution of 125 I cerebrolysin in mouse show that cerebrolysin can pass through blood brain barrier and its remaining time in brain is longer relatively than that in other tissues. It suggests that the brain have a function of taking up 125 I cerebrolysin.

关 键 词：脑活肽 生物分布 碘125标记 氯胺T法 

分 类 号：R817.1[医药卫生—影像医学与核医学] R971[医药卫生—放射医学]