噬菌体裂解酶在医疗卫生中的应用及展望  

Application and Prospect of Bacteriophage Lysins in Medicine

作　　者：王爽[1,2] 郝丽梅[1] 段惠莉[1] 杨革[2] 祁建城[1] 

机构地区：[1]军事医学科学院卫生装备研究所国家生物防护装备工程技术研究中心,天津300161 [2]曲阜师范大学生命科学学院,山东曲阜273165

出　　处：《环境与健康杂志》2009年第2期185-187,共3页Journal of Environment and Health

摘　　要：噬菌体裂解酶是由双链DNA噬菌体编码的在基因组复制晚期合成的一类蛋白质,它能够水解细菌细胞壁的肽聚糖从而杀灭细菌。噬菌体裂解酶在体内外的实验中都表现出了很高的杀菌性、种属特异性和安全性,因而具有广阔的应用前景。该文从噬菌体裂解酶的结构性质,对不同致病菌的抗菌性能及在医疗卫生中的应用进行综述。Bacteriophage lysins are double-stranded DNA bacteriophage-encoded peptidoglycan hydrolases produced in phage-infected bacterial cells toward the end of the lyric cycle. It was proved that the phage lysins have a narrow antibacterial spectrum, high activity against bacteria regardless of their antibiotic sensitivity, and apparent safety in vitro and vivo experiments. Those paved solid foundation for further exploration of their application. This paper presented a review on the structure and mode of action of lysins, antibacterial characteristics, and their application in medicine.

关 键 词：微生物 噬菌体 裂解酶 医疗卫生 

分 类 号：R117[医药卫生—公共卫生与预防医学]