核素动态显像对狗股骨头缺血性坏死的早期血流灌注测定  

The early assessment of avascular necrosis of femur head in dogs by dynamic bone imaging

作　　者：李培勇[1] 张欢[1] 张翼先[1] 朱承谟[1] 孙争鸣[1] 杨庆铭[1] 

机构地区：[1]上海第二医科大学附属瑞金医院,上海200025

出　　处：《核技术》1998年第5期279-283,共5页Nuclear Techniques

基　　金：1995年卫生部课题

摘　　要：以病理切片为依据，手术冷冻建立起10条狗股骨头缺血性坏死的早期模型．在术前和术后1、3、5、7、12、19、33天分别作99mTc－MDP股骨头动态显像，测定股骨头血流灌注指数（FPI），以对股骨头缺血性坏死的早期血流变化进行探讨。结果显示，股骨头缺血性坏死的早期病理可分别分为骨髓组织水肿、髓腔内出血、脂肪溶解液化、肉芽组织及新骨形成等四期。骨动态显像后的FPI显示，手术侧股骨头血流灌注下降，术后前19天股骨头处放射性稀疏，术后33天股骨头放射性浓聚。股骨头动态显像测定股骨头血流灌注有助于股骨头缺血的早期诊断。Avascular necrosis of femoral head (AVN) was induced unilaterally in 10 dogs byfrozen. Dynamic bone Anaging was performed before, and 1, 3, 5, 7, 12, 19 and 33 daysafter operation. The perfusion index of femoral head (FPI) was calculated by thegraphical approach of time-activity curves and quantitation of data. Based onhistological examination, pathological lesions on 10 dogs could be classified into fourstages: edema, hemorrhage, liquidation, and granulation formation with focal fibrosis,etc. Decreased FPI index was found in all lesions of 10 dogs by dynamic boneimaging. Until 19 days after operation, the uptake was reduced compared to thenormal side, whereas after 33 days, its uptake was increased. Perfusion index wasconsidered to reveal the blood flow condition in femoral head. It can be used todetect the early stage of AVN and to understand the effects of various modes oftherapy.

关 键 词：股骨头坏死 骨动态显像 血流灌注 核素 锝99M 

分 类 号：R817.48[医药卫生—影像医学与核医学] R683.42[医药卫生—放射医学]