一种肾脏显像剂的研制  

An experimental study on a renal imaging agent

作　　者：朱珺[1] 马寄晓[1] 朱瑞森[1] 熊江[1] 金常青[1] 

机构地区：[1]上海市第六人民医院,上海200233

出　　处：《核技术》1998年第5期297-300,共4页Nuclear Techniques

摘　　要：报道自行合成氯化N－甲基吡哆醛（SB）。研究了甘氨酸（Gly）、丙氨酸（Ala）、甘氨酸乙酯（GlyOEt）与SB形成的碱，在SnCl2·2H2O的存在下，与锝螯合后体内的代谢；还研究了影响标记率的因素和标记的最佳方法。用99mTc－SB－Gly作动物实验的研究结果表明：这种阳离子螯合剂静脉注射后均能快速地经肾脏排出体外，30min尿排泄率为79．68±6．66ID％，略低于99mTc－DTPA（82．56±6．88ID％）。肾动态显影清晰，肝胆排泄甚少，血液清除速率较快，清除曲线符合二项分布。毒性实验证实标记物有足够的安全性。丙磺舒抑制实验中，尿排泄率并未被丙磺舒所抑制，提示可能是肾小球滤过型。The authors reported the reactions of glycine, alycine and glycine ethyl esterwith pyridoxal chloride to form the base and the compound chelated with 99mTc in thepresence of SnCl2· 2H2O. The metabolism of this compound in vivo was alsoobserved. The influencing factors were studied and the best labelling procedures wereobtained. The animal experiment on 99mTc-SB-Gly indicated that this agent could berapidly excreted through the kidney into the urine after intravenous injection, withan excretory rate of 79.68± 6.66ID% in 30min via urine, a little bit lower than99mTc-DTPA (82.56 ± 6.88ID%), but having a clear renal scintigraphy. Besides, theelimination of blood was rapid and the labelling compound had enough safety. Ininhibition experiments with probencid in rats, the urine excretion rate was notaffected, suggesting that this compound passed through by glomerular filtration.

关 键 词：肾显像剂 锝99M 同位素标记 

分 类 号：R817.47[医药卫生—影像医学与核医学]