^(125)I-BMIPP在SD鼠体内的分布以及血流改变对其在心肌中分布的影响  

Tissue distribution of ^(125)I-BMIPP in SD rats and the effect of blood flow on myocardial uptake of BMIPP

作　　者：李京波[1] 黄钢[1] 李志善[1] 刘平安 

机构地区：[1]上海医科大学附属中山医院

出　　处：《核技术》1998年第5期317-320,共4页Nuclear Techniques

基　　金：卫生部优秀青年基金!Q9423

摘　　要：报道了125I标记的15－（对－碘苯）3－（R，S）－甲基－十五烷酸（BMIP）在SD鼠体内的分布以及血流改变对其在心肌中分布的影响。结果显示，SD鼠心肌摄取125I－BMIPP在5min时为3．86％ID／g，且5－60min保持稳定；30min时心／血、心／肺、心／肝比值分别为1．56、2．08和1．62，而125I－BMIPP在肝脏中的清除则较快。对照组心肌摄取125I－BMIPP及心／血比值分别为3．27±0．32％ID／g和1．56±0．09；与正常对照组相比，双嘧达莫组心肌对125I－BMIPP摄取（3．90±0．25％ID／g）及心／血比值（1．79±0．17）明显增高（P＜0．05）。表明BMIPP在心肌中的滞留时间较长且能反映心肌的血流灌注，故BMIPP可作为心肌瘤注示踪剂而适宜于SPECT显像。The tissue distribution of 125I-BMIPP in Sprague-Dawley (SD) rats and theeffect of blood now on myocardial uptake of BMIPP were reported. The resultshowed myocardial uptake at 5 min after 125I-BMIPP injection was 3.86%ID/g andremained constant up to 60 min. The ratios of myocardium/blood andmyocardium/lung as well as myocardium/liver were 1.56, 2.08 and 1.62 respectively at30 min. The liver showed rapid clearance of 125I-BMIPP. In dipyridamole group,myocardial uptake of 125I-BMIPP (3.90±0.25%ID/g) and myocardium/blood ratio(1.79± 0.17) were signilicantly increased (P<0.05) than those of the normal control(3.27± 0.32%ID/g and 1.56± 0.09). Therefore, BMIPP showed higher myocardialuptake and longer myocardial retention and can refiect myocardial perfusion, so itcan be used as myocardial perfusion tracers for SPECT

关 键 词：碘125 BMIPP 体内分布 放射性核素显像 心肌分布 

分 类 号：R817.42[医药卫生—影像医学与核医学]