均匀设计法优选制备复方天麻滴丸的最佳工艺  

Optimization of Preparation Procedure of Compound Tall Gastrodia Tuber Drop Pill by Uniform Design

作　　者：程冀[1,2] 季宇彬[1,2] 李文兰[1,2] 扈正婷[1,2] 徐栋[1,2] 

机构地区：[1]哈尔滨商业大学生命科学与环境科学研究中心,黑龙江哈尔滨150076 [2]国家教育部抗肿瘤天然药物工程研究中心,黑龙江哈尔滨150076

出　　处：《食品与药品》2009年第1期18-20,共3页Food and Drug

基　　金：黑龙江省科技厅攻关项目(GC03C614-1)

摘　　要：目的研究制备复方天麻滴丸的最佳工艺。方法选用U9(94)进行均匀设计优选滴丸的制备工艺。以硬度、拖尾、粘连及综合结果为指标,考察基质与药物之比、PEG4000与PEG6000之比、料温(溶解药物基质的温度)及滴距(滴管口与冷却液面之间的距离)对制备滴丸的影响。结果最佳的工艺条件为:基质与药物的比例为7∶1,PEG4000与PEG6000之比为1∶5,料温96℃,滴距5cm。结论均匀设计法是优化复方天麻滴丸制备工艺的有利工具。Objective To study the optimum preparation procedure of compound tall gastrodia tuber drop pill. Methods The optimization of preparation procedure of compound tall gastrodia tuber drop pill was performed by U9（94） uniform design method. With hardness, tailing, adhesion and comprehensive result as investigative indexes, the influences of ratio of base to drug, ratio of PEG 4000 to PEG 6000, material temperature and dropping distance on the preparation of drop pill were studied. Results The optimum preparation procedure was as follows： ratio of base to drug of 7 ： 1, ratio of PEG 4000 to PEG 6000 of 1 ： 5, material temperature of 96 ℃ and dropping distance of 5cm. Conclusion The uniform design is a good method for the optimization of preparation procedure of compound tall gastrodia tuber drop.

关 键 词：均匀设计 滴丸 制备工艺 

分 类 号：R282.71[医药卫生—中药学]