胰岛素抵抗和C反应蛋白与子痫前期的相关性研究  

Association of insulin resistance, c-reactive protein with preeclampsia

作　　者：吴向华[1] 段明英[1] 张素霞[1] 董娟[1] 李亚钦[1] 

机构地区：[1]济南市妇幼保健院产科,山东济南250001

出　　处：《中国现代医学杂志》2009年第3期427-429,共3页China Journal of Modern Medicine

摘　　要：目的探讨妊娠中期稳态模型的胰岛素抵抗指数及C反应蛋白水平与子痫前期发生的关系。方法对2005年9月～2006年12月来该院门诊产前检查的妊娠20～26周孕妇进行前瞻性研究分析;根据妊娠结局将孕妇分为子痫前期组28名及正常妊娠组32名。空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)和C反应蛋白(CRP)进行对数转换为lgINS、lgIR和lgCRP,对观察指标和孕妇结局进行统计学分析。结果子痫前期组的平均动脉压(MABP)、lgINS、lgIR、lgCRP分别明显高于正常妊娠组(P<0.01);HOMA-IR与CRP呈正相关(P<0.01),二者均与MABP呈正相关(P<0.05),二者均与BMI无明显相关性(P>0.05)。结论孕中期胰岛素抵抗指数和C反应蛋白升高可能与以后子痫前期的发生有关。[Objective] To explore the association of homeostatic model assessment - insulin resistance index （HOMA-IR） and c-reactive protein （CRP） concentration in the second trimester of pregnancy with preeelampsia（PE）. [Methods] A prospeetive observational study was earried out on the women in 20-26 gestational weeks who were admitted to our department from September 2005 to December 2006. They were divided into preeelampsia group （PE, 28 eases） and eontrol group （normal pregnancy,32 cases） according to gestational outcomes, Lg-transformed fasting blood insulin （FINS）, HOMA-IR, CRP （lgINS, lgIR, IgCRP） was used in the statistical analysis.The relations between the elinical observations and maternal outcomes were analyzed. [Results] Compared with normal pregnancy, PE showed signifieanfly higher levels of MABP, lgINS, lgIR, lgCRP （P 〈0.05～0.01）. There were positive correlation between HOMA-IR and CRY （P 〈0.01）, and beth of them were correlated positively with MABP （P 〈0.05）, but both of them were not eorrelated with BMI （P 〉0.05）. [Conclusion] The detection of HOMA-IR and c-reactive protein in the second trimester of pregnancy may be related to the development of PE.

关 键 词：子痫前期 胰岛素抵抗 C反应蛋白 

分 类 号：R714.244[医药卫生—妇产科学]